Elevated soluble interleukin-2 receptors in young healthy cigarette smokers: lack of association with atopy or airways hyperresponsiveness.
Elevated soluble interleukin-2 receptors in young healthy cigarette smokers: lack of association with atopy or airways hyperresponsiveness.
复制标题
年轻健康吸烟者的可溶性白细胞介素 2 受体升高：与特应性或气道高反应性缺乏关联。
DOI：
10.1159/000236091
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发表时间：
1992
影响因子：
2.8
通讯作者：
Leung,DY
中科院分区：
文献类型：
--
作者：
Tollerud,DJ;Weiss,ST;Leung,DY
为探讨特应性和非特异性呼吸道高反应性与循环中可溶性白介素2受体(sIL-2R)水平的关系，我们测定了40例健康吸烟者和40例非吸烟者血清sIL-2R水平。目前吸烟者的sIL-2R水平显著高于非吸烟者(中位数分别为605U/ml和398U/ml；p<；0.05)。血清sIL-2R水平与非特异性呼吸道对乙酰甲胆碱的高反应性、过敏皮试反应、医生诊断的哮喘或花粉热或喘息性呼吸道症状无关。在目前的吸烟者中，在报告有痰分泌症状的受试者中观察到了更高的sIL-2R水平(没有统计学意义)的趋势。与吸烟相关的sIL-2R水平的增加在幅度上与免疫调节疾病如胶原、血管疾病和湿疹的报道相似。这些数据证实，吸烟是sIL-2R水平的一个重要决定因素，即使在年轻的健康受试者中也是如此。这一效应似乎与特应性状态或支气管反应性无关。在吸烟者中，sIL-2R水平可能与痰产生相关条件的存在有关。
To study the relationship of atopy and nonspecific airways hyperresponsiveness to circulating levels of soluble interleukin-2 receptors (sIL-2R), we measured serum sIL-2R concentrations in 40 young, healthy smokers and non-smokers. Levels of sIL-2R were significantly higher in current smokers than in nonsmokers (median sIL-2R levels 605 vs. 398 U/ml, respectively; p < 0.05). Serum sIL-2R levels were not related to nonspecific airways hyperresponsiveness to methacholine, allergy skin test reactivity, doctor-diagnosed asthma or hay fever, or respiratory symptoms of wheeze. Among current smokers, a trend toward higher sIL-2R levels (not statistically significant) was observed among subjects reporting symptoms of phlegm production. The increase in sIL-2R levels associated with cigarette smoking was similar in magnitude to that reported for immune-mediated conditions such as collagen vascular diseases and eczema. These data confirm that cigarette smoking is an important determinant of sIL-2R level, even among young healthy subjects. This effect does not appear to be related to atopic status or bronchial responsiveness. Among cigarette smokers, sIL-2R level may be related to the presence of conditions associated with phlegm production.