Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes
Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes
复制标题
Ellobius物种的基因组提供了对哺乳动物性染色体进化动力学的深入了解
作者：
Eskeatnaf Mulugeta;Eskeatnaf Mulugeta;Evelyne Wassenaar;E. Sleddens;W. Ijcken;E. Heard;J. Grootegoed;W. Just;J. Gribnau;W. Baarends
有胎盘哺乳动物的X和Y性染色体显示了动荡的进化历史的标志。X染色体具有丰富和保守的基因内容，而Y染色体已经丢失了大部分基因。外高加索鼹鼠Ellobius lutescens中，包括Sry在内的Y染色体已丢失，雌性和雄性均具有17，X二倍体核型。相似地，密切相关的Ellobius talpinus在雌性和雄性中都具有54，XX核型。在这里，我们报告了E. lutescens和E. talpinus基因组。结果表明，E. lutescens和E. Talpinus发生在两个独立的事件中。在雌性和雄性E. lutescens，其中3株在E. talpinus基因组。其中之一是Eif 2s3 y，它被称为唯一对成功的男性减数分裂至关重要的Y源基因。雌雄E.黄体癌可以携带一个相同的X染色体，具有很大程度上保守的基因内容，包括已知在X染色体失活中起作用的所有基因。这些鼹鼠物种的基因组的可用性提供了独特的模型来研究性染色体进化的动态。
The X and Y sex chromosomes of placental mammals show hallmarks of a tumultuous evolutionary past. The X Chromosome has a rich and conserved gene content, while the Y Chromosome has lost most of its genes. In the Transcaucasian mole vole Ellobius lutescens, the Y Chromosome including Sry has been lost, and both females and males have a 17,X diploid karyotype. Similarly, the closely related Ellobius talpinus, has a 54,XX karyotype in both females and males. Here, we report the sequencing and assembly of the E. lutescens and E. talpinus genomes. The results indicate that the loss of the Y Chromosome in E. lutescens and E. talpinus occurred in two independent events. Four functional homologs of mouse Y-Chromosomal genes were detected in both female and male E. lutescens, of which three were also detected in the E. talpinus genome. One of these is Eif2s3y, known as the only Y-derived gene that is crucial for successful male meiosis. Female and male E. lutescens can carry one and the same X Chromosome with a largely conserved gene content, including all genes known to function in X Chromosome inactivation. The availability of the genomes of these mole vole species provides unique models to study the dynamics of sex chromosome evolution.
影响因子：
11.8
作者：
Deng, Xinxian;Berletch, Joel B.;Ma, Wenxiu;Nguyen, Di Kim;Hiatt, Joseph B.;Noble, William S.;Shendure, Jay;Disteche, Christine M.
通讯作者：
Disteche, Christine M.