GCF IL-1β profiles in periodontal disease
GCF IL-1β profiles in periodontal disease
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DOI：
10.1034/j.1600-051x.2002.290108.x
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发表时间：
2002-01-01
影响因子：
6.7
通讯作者：
Lamster, IB
中科院分区：
文献类型：
--
作者：
Engebretson, SP;Grbic, JT;Lamster, IB
目的：研究提示遗传因素对牙周沟液中白细胞介素1β(IL-1β)水平的影响。然而，牙周膜中IL-1β的水平也取决于采集部位的临床参数，包括探测深度(PD)和附着水平(AL)。为了研究这个问题，我们从不同程度的牙周病患者身上检测了牙周液中的IL-1β。材料与方法：对29例轻、中、重度不吸烟成人牙周病患者，分别于治疗前、治疗后2周、治疗后24周，采用双抗体夹心法测定牙周组织中6~8个磨牙部位的牙周液IL-1β水平。为了以后的分析，根据疾病的严重程度(轻度/中度与重度)将患者分为两组。结果：PD和AL均与基线时的IL-1β水平密切相关。然而，病情严重的患者在各个帕金森病类别中的IL-1β水平均高于轻中度疾病患者。与轻、中度疾病患者相比，重症患者浅表部位IL-1β水平升高近2倍(P
Objectives: Studies suggest a genetic influence on levels of interleukin-1beta (IL-1beta) in gingival crevicular fluid (GCF). Levels of IL-1beta in GCF, however, are also dependent upon the clinical parameters at the site of collection, including probing depth (PD) and level of attachment (AL). To examine this issue, IL-1beta in GCF was evaluated from patients with varying degrees of periodontal disease. The influence of both the status of the patient and the probing depth at the sampled sites were considered in the analysis.Material and methods: GCF IL-1beta was determined by ELISA at 6-8 molar sites from 29 non-smoking adults with mild, moderate, or severe periodontal disease at baseline, 2 weeks, and 24 weeks following scaling and root planing. For later analysis, patients were dichotomized on the basis of disease severity (mild/moderate vs severe). Sampled sites were classified at baseline by PD as, shallow (6 mm).Results: PD and AL were each strongly correlated with IL-1beta levels at baseline. However, patients with severe disease had higher levels of IL-1beta in each PD category than those with mild/moderate disease. As compared to patients with mild/ moderate disease, IL-1beta levels in shallow sites from patients with severe disease was elevated nearly 2 fold (p