Depression and familial risk for substance dependence: a P300 study of young women
Depression and familial risk for substance dependence: a P300 study of young women
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DOI：
10.1016/s0925-4927(03)00074-x
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发表时间：
2003-09-30
影响因子：
2.3
通讯作者：
Hesselbrock, VM
中科院分区：
文献类型：
--
作者：
Houston, RJ;Bauer, LO;Hesselbrock, VM
本研究评估了抑郁症和酒精或物质依赖家族史对14至20岁年轻女性P300事件相关电位的影响。在130名女性受试者中，29名符合DSM-III-R诊断标准，即终生有严重抑郁发作史。事件相关的脑电图记录从每个主题，而她执行了一个复杂的视觉古怪的任务。分析表明，与没有抑郁症史的女孩相比，抑郁症组的P300振幅减少。没有发现酒精中毒或药物依赖的家族史的影响。电流源密度分析，利用一个现实的头形边界元模型，表明抑郁症和非抑郁症组之间的差异是最大的右前额叶区域。这些结果进一步支持了这样一种观点，即与抑郁症相关的认知困难是微妙的，最好用敏感的神经生理指标（如P300）检测。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
The present study evaluated the effects of depression and a family history of alcohol or substance dependence on P300 event-related potentials in young women aged 14 to 20 years. Of the 130 female subjects, 29 met DSM-III-R diagnostic criteria for a lifetime history of a Major Depressive Episode. Event-related electroencephalographic potentials were recorded from each subject while she performed a complex visual oddball task. Analyses indicated a decrement in P300 amplitude in the depressed group as compared to girls with no history of depression. No effects of family history of alcoholism or drug dependence were detected. Current source density analyses, utilizing a realistic head-shape boundary element model, indicated that the difference between the depressed and non-depressed groups was maximal in the right prefrontal region. These results provide further support for the notion that the cognitive difficulties associated with depression are subtle and best detected with sensitive neurophysiological indices, such as P300. (C) 2003 Elsevier Ireland Ltd. All rights reserved.