Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis - A diffusion-tensor magnetic resonance imaging study
Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis - A diffusion-tensor magnetic resonance imaging study
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DOI：
10.1001/archneur.59.9.1406
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发表时间：
2002-09-01
影响因子：
--
通讯作者：
Filippi, M
中科院分区：
文献类型：
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作者：
Rovaris, M;Bozzali, M;Filippi, M
背景：扩散张量磁共振成像对 T2 可见病变外部和内部发生的多发性硬化症 (MS) 演变的更具破坏性的方面敏感，因此，与传统磁共振成像相比，有望提供更完整的原发性进行性 (PP) MS 相关组织损伤图像。 目的：通过使用扩散张量磁共振评估大脑正常白质和灰质中隐匿病理特征的程度，提高我们对 PPMS 的理解方法：对 96 名 PPMS 患者、47 名继发进展型 (SP) MS 患者和 44 名健康对照受试者进行了研究。计算T2高信号和T1低信号病变体积，并测量整个脑组织的体积。对弥散张量磁共振成像扫描进行后处理和分析，以获得大脑以及独立出现的正常白质和灰质的平均弥散率和分数各向异性直方图。结果：PPMS 患者的平均 T2 高信号和 T1 低信号病变体积低于 SPMS 患者，而两组的平均绝对脑体积相似。 SPMS 患者的平均病灶扩散率显着高于 PPMS 患者（P
Background: Diffusion-tensor magnetic resonance imaging is sensitive to the more destructive aspects of multiple sclerosis (MS) evolution occurring outside and within T2-visible lesions and, as a consequence, holds promise for providing a more complete picture of primary progressive (PP) MS-related tissue damage than conventional magnetic resonance imaging.Objective: To improve our understanding of PPMS by assessing the extent of occult pathological features in the normal-appearing white and gray matter of the brain using diffusion-tensor magnetic resonance imaging.Methods: Ninety-six patients with PPMS, 47 patients with secondary progressive (SP) MS, and 44 healthy control subjects were studied. T2-hyperintense and T1-hypointense lesion volumes were calculated, and the volume of the whole brain tissue was measured. Diffusion-tensor magnetic resonance imaging scans were postprocessed and analyzed to obtain the mean diffusivity and fractional anisotropy histograms from the brain and from the normal-appearing white and gray matter in isolation.Results: The mean T2-hyperintense and T1-hypointense lesion volumes were lower in patients with PPMS than in patients with SPMS, while the mean absolute brain volumes were similar in the 2 groups. The average lesion diffusivity was significantly higher in patients with SPMS than in patients with PPMS (P