Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI).
Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI).
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DOI：
10.1039/c4cc05803h
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发表时间：
2014-11
影响因子：
4.9
通讯作者：
Haijie Tong;C. Fitzgerald;P. Gallimore;Markus Kalberer;M. Kuimova;Peter C. Seville;Andrew D. Ward;F. D. Pope
中科院分区：
文献类型：
--
作者：
Haijie Tong;C. Fitzgerald;P. Gallimore;Markus Kalberer;M. Kuimova;Peter C. Seville;Andrew D. Ward;F. D. Pope
来自Salamol®药物吸入器的单个微米大小的固体颗粒首次使用光学捕集器在空气中稳定捕获。悬浮颗粒的拉曼光谱可以在高湿环境中模拟颗粒从吸入器到肺部的旅行，从而在线询问其组成和潮解相变化。
Individual micron-sized solid particles from a Salamol® pharmaceutical inhaler are stably captured in air using an optical trap for the first time. Raman spectroscopy of the levitated particles allows online interrogation of composition and deliquescent phase change within a high humidity environment that mimics the particle's travel from inhaler to lung.