Mood and male sexual behaviour in the APP23 model of Alzheimer's disease
Mood and male sexual behaviour in the APP23 model of Alzheimer's disease
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DOI：
10.1016/j.bbr.2007.03.002
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发表时间：
2007-06
影响因子：
2.7
通讯作者：
E. Vloeberghs;D. V. Dam;F. Franck;M. Staufenbiel;P. Deyn
中科院分区：
文献类型：
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作者：
E. Vloeberghs;D. V. Dam;F. Franck;M. Staufenbiel;P. Deyn
阿尔茨海默氏症的特点是认知能力下降和出现一系列神经精神障碍，其中包括情感障碍、刻板印象行为、饮食过度活跃和性行为变化。转基因的APP23小鼠建立了阿尔茨海默病的模型，并已被证明是研究这种疾病的独特工具。与痴呆症患者类似，APP23小鼠除了年龄相关的认知能力下降外，还会出现一系列行为问题，如昼夜活动紊乱和攻击性增加。本研究旨在调查该模型是否也会导致情绪障碍和性行为的改变。使用两种行为绝望范式和蔗糖偏好检验，我们没有发现与抑郁相关的行为发展的证据。一个复杂的方案都不能揭示APP23和WT小鼠之间雄性性行为的变化。然而，本研究提供的证据表明，与对照仔鼠相比，APP23小鼠更焦虑和恐惧，这为未来的治疗研究打开了前景。
Alzheimer's disease is characterised by both cognitive deterioration and the development of a wide range of neuropsychiatric disturbances, among which affective disturbances, stereotyped behaviour, dietary hyperactivity and changes in sexual behaviour. The transgenic APP23 mouse models Alzheimer's disease and has shown to be a unique tool in the study of this condition. APP23 mice develop, next to the age-dependent cognitive decline, also a range of behavioural problems, such as circadian activity disturbances and increased aggression, in analogy with the dementing patients. The present study aimed to investigate whether this model also develops mood disturbances and changes in sexual behaviour. Using two behavioural despair paradigms and the sucrose preference test, we did not find evidence for the development of depression-related behaviours. A sophisticated protocol was neither able to unravel changes in male sexual behaviour between APP23 and WT mice. The present study nevertheless provides evidence that the APP23 mice are more anxious and fearful in comparison with control littermates, which opens perspectives to future treatment studies.