Targeting axon guidance cues for neural circuit repair after spinal cord injury.
Targeting axon guidance cues for neural circuit repair after spinal cord injury.
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脊髓损伤后神经回路修复的靶向轴突引导线索。
DOI：
10.1177/0271678x20961852
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Zou Y
中科院分区：
文献类型：
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作者：
Zou Y
至少三分之二的脊髓损伤病例在解剖学上是不完整的，没有完全的脊髓横断，尽管最初的损伤导致感觉和运动功能的完全丧失。神经回路和网络的可塑性允许在成功的康复训练后，某些个体的功能恢复程度不同。然而，在大多数情况下，效率和程度都是有限的和不确定的，主要是由于许多障碍的修复。解剖学上不完全损伤后的功能恢复部分是通过新轴突或新轴突分支穿过备用脊髓组织的生长以及它们形成的新突触连接而实现的，所述新轴突或新轴突分支沿着它们生长穿过的区域或在它们终止的区域中。本文将讨论轴突导向分子，特别是Wnt家族蛋白在脊髓损伤中的作用的新进展，以及如何应用轴突导向的知识和工具来增加恢复的潜力。这些策略与其他策略相结合，如神经保护和康复，可能会带来新的希望。解剖学上不完全脊髓损伤的恢复策略是相关的，可能适用于创伤性脑损伤和中风。
At least two-thirds of spinal cord injury cases are anatomically incomplete, without complete spinal cord transection, although the initial injuries cause complete loss of sensory and motor functions. The malleability of neural circuits and networks allows varied extend of functional restoration in some individuals after successful rehabilitative training. However, in most cases, the efficiency and extent are both limited and uncertain, largely due to the many obstacles of repair. The restoration of function after anatomically incomplete injury is in part made possible by the growth of new axons or new axon branches through the spared spinal cord tissue and the new synaptic connections they make, either along the areas they grow through or in the areas they terminate. This review will discuss new progress on the understanding of the role of axon guidance molecules, particularly the Wnt family proteins, in spinal cord injury and how the knowledge and tools of axon guidance can be applied to increase the potential of recovery. These strategies, combined with others, such as neuroprotection and rehabilitation, may bring new promises. The recovery strategies for anatomically incomplete spinal cord injuries are relevant and may be applicable to traumatic brain injury and stroke.