egl-4 acts through a transforming growth factor-beta/SMAD pathway in Caenorhabditis elegans to regulate multiple neuronal circuits in response to sensory cues.
egl-4 acts through a transforming growth factor-beta/SMAD pathway in Caenorhabditis elegans to regulate multiple neuronal circuits in response to sensory cues.
复制标题
egl-4 通过秀丽隐杆线虫中的转化生长因子-β/SMAD 途径发挥作用，调节多个神经元回路以响应感觉线索。
DOI：
10.1093/genetics/156.1.123
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发表时间：
2000
期刊：
影响因子：
3.3
通讯作者：
Sengupta,P
中科院分区：
文献类型：
--
作者：
Daniels,SA;Ailion,M;Thomas,JH;Sengupta,P
感觉线索调节秀丽隐杆线虫的几个方面的行为和发育，包括进入和退出另一个发育阶段，称为幼虫。三个平行通路，包括TGF-β样通路，调节水的形成。感官信号调节这些通路活动的机制在很大程度上是未知的。geneegl-4最初是根据其产卵缺陷确定的。我们在这里表明，策略-4具有许多多效性，包括在化学感觉行为、体型、突触传递和水形成方面的缺陷。我们的结果与foregl-4在将感觉线索传递给秀丽隐杆线虫的多种行为和发育回路中的作用是一致的。通过上位性分析，我们还将egl-4置于TGF-β样分支中，并表明SMAD基因在多种egl-4调控途径（包括化学感觉）中发挥着egl-4下游的作用。
Sensory cues regulate several aspects of behavior and development inCaenorhabditis elegans, including entry into and exit from an alternative developmental stage called the dauer larva. Three parallel pathways, including a TGF-β-like pathway, regulate dauer formation. The mechanisms by which the activities of these pathways are regulated by sensory signals are largely unknown. The geneegl-4was initially identified based on its egg-laying defects. We show here thategl-4has many pleiotropies, including defects in chemosensory behavior, body size, synaptic transmission, and dauer formation. Our results are consistent with a role foregl-4in relaying sensory cues to multiple behavioral and developmental circuits inC. elegans.By epistasis analysis, we also placeegl-4in the TGF-β-like branch and show that a SMAD gene functions downstream ofegl-4in multipleegl-4-regulated pathways, including chemosensation.