Serum phospholipid transfer protein activity after a high fat meal in patients with insulin-treated type 2 diabetes.
Serum phospholipid transfer protein activity after a high fat meal in patients with insulin-treated type 2 diabetes.
复制标题
胰岛素治疗的 2 型糖尿病患者高脂餐后血清磷脂转移蛋白活性。
DOI：
10.1007/s11745-010-3384-5
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发表时间：
2010
期刊：
影响因子：
1.9
通讯作者：
Jiang,Xian-Cheng
中科院分区：
文献类型：
--
作者：
Schlitt,Axel;Schwaab,Bernhard;Fingscheidt,Kirsten;Lackner,KarlJ;Heine,GunnarH;Vogt,Alexander;Buerke,Michael;Maegdefessel,Lars;Raaz,Uwe;Werdan,Karl;Jiang,Xian-Cheng
血浆磷脂转移蛋白（PLTP）介导不同脂蛋白之间磷脂的净转移和交换。动物研究表明，它与动脉粥样硬化的发生密切相关。虽然许多研究表明，PLTP活性在糖尿病中升高，但PLTP在糖尿病中的作用尚不清楚。为了评估高脂肪膳食对PLTP活性的影响，我们纳入了50名非糖尿病合并冠心病（CHD）患者、50名胰岛素治疗的2型糖尿病患者和50名健康对照。我们测定了高脂肪餐前、餐后4和8小时PLTP的活性。正如预期的那样，冠心病患者的血清PLTP活性在基线时显著高于健康对照组（71.0±46.2 vs. 54.0±33.8 pmol/μl/h，P= 0.032）。更重要的是，我们发现无论在对照组还是冠心病患者，在脂肪负荷后4小时，血清PLTP活性都上升到最大值，8小时后又下降到接近基础水平。相比之下，糖尿病患者的PLTP活性在此期间持续升高。根据这项研究的数据，我们假设血清PLTP参与餐后脂蛋白的清除，而这一过程在糖尿病患者中减弱。由于餐后脂蛋白具有致动脉粥样硬化的作用，因此这些颗粒清除的延迟可能在糖尿病患者动脉粥样硬化的发展中起重要作用。
Plasma phospholipid transfer protein (PLTP) mediates both net transfer and exchange of phospholipids between different lipoproteins. Animal studies have shown that it is closely related to the development of atherosclerosis. Although many studies have indicated that PLTP activity is increased in diabetes mellitus, the role of PLTP in diabetes is still unclear. To evaluate the influence of a high-fat meal on PLTP activity, 50 nondiabetic patients with coronary heart disease (CHD), 50 insulin-treated Type 2 diabetics, and 50 healthy controls were included. We determined PLTP activity before and 4 and 8 h after a high-fat meal. As expected, serum PLTP activity was significantly higher in CHD patients than in healthy controls (71.0 ± 46.2 vs. 54.0 ± 33.8 pmol/μl/h,P= 0.032) at baseline. More importantly, we found that serum PLTP activity increased to its maximum 4 h after fat loading and then decreased to nearly basal levels after 8 h both in controls and CHD patients. In contrast, PLTP activity continuously increased during this time period in the diabetic patients. With regards to the data from this study we hypothesize that serum PLTP is involved in the clearance of postprandial lipoproteins and this process is attenuated in diabetes. Since postprandial lipoproteins are atherogenic, the delay in clearance of these particles could play an important role in the development of atherosclerosis in patients with diabetes mellitus.