The contribution of nitro- and methylnitro-naphthalenes to the vapor-phase mutagenicity of ambient air samples
The contribution of nitro- and methylnitro-naphthalenes to the vapor-phase mutagenicity of ambient air samples
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DOI：
10.1016/1352-2310(96)00024-6
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发表时间：
1996-09-01
影响因子：
5
通讯作者：
Arey, J
中科院分区：
文献类型：
--
作者：
Gupta, P;Harger, WP;Arey, J
对加利福尼亚州雷德兰兹地区中度光化学空气污染期间采集的环境气相样品中的1-和2-硝基萘(NN)以及14种甲基硝基萘(MNN)异构体进行了鉴定和定量。用Ames沙门氏菌细菌回复试验的微悬液预育改良法测定了NN和MNN标准品对TA98菌株的致突变活性。NNS和MNN对气相环境诱变总活性的计算贡献分别类似于18%和32%(白天和夜间复合样品)。夜间样品的诱变活性增强归因于夜间N3自由基引发的萘和甲基萘反应生成NN和MNN。版权所有(C)1996爱思唯尔科学有限公司
1- and 2-Nitronaphthalene (NN) and the 14 methylnitronaphthalene (MNN) isomers were identified and quantified in ambient vapor-phase samples collected in Redlands, CA during moderate photochemical air pollution. The mutagenic activities of NN and MNN standards were determined using a microsuspension-preincubation modification of the Ames Salmonella bacterial reversion assay in strain TA98 without microsomal activation. The calculated contributions of the NNs and MNNs to the total vapor-phase ambient mutagenic activity were similar to 18 and similar to 32% for daytime and nighttime composite samples, respectively. Enhanced mutagenic activity in the nighttime sample was attributed to NN and MNN formation from nighttime NO3 radical-initiated reactions of naphthalene and the methylnaphthalenes. Copyright (C) 1996 Elsevier Science Ltd