Reversible ON/OFF nanoswitch for organocatalysis: mimicking the locking and unlocking operation of CaMKII.
Reversible ON/OFF nanoswitch for organocatalysis: mimicking the locking and unlocking operation of CaMKII.
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DOI：
10.1002/anie.201108089
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发表时间：
2012-04
影响因子：
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通讯作者：
M. Schmittel;Soumen De;Susnata Pramanik
中科院分区：
文献类型：
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作者：
M. Schmittel;Soumen De;Susnata Pramanik
扳动开关：纳米开关使用化学输入来开启和关闭有机催化的诺文格尔反应(见方案：R=反应物，P=产物)。为了停止催化，化学输入(粉色和绿色)包裹着纳米开关的抑制段，以实现开关的释放或解锁。该过程可以在三个周期内可逆运行，而不会失去活性。
Flip a switch: a nanoswitch uses chemical inputs to turn an organocatalytic Knoevenagel reaction on and off (see scheme: R=reactant, P=product). To stop catalysis the chemical input (pink and green) wraps around the inhibitory segment of the nanoswitch to effect release or unlocking of the switch. The process can run reversibly over three cycles without loss of activity.