How ubiquitin functions with ESCRTs.
How ubiquitin functions with ESCRTs.
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DOI:
10.1111/j.1600-0854.2011.01242.x
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发表时间:
2011-10
期刊:
影响因子:
--
通讯作者:
Piper RC
中科院分区:
文献类型:
--
作者:
Shields SB;Piper RC
The ESCRT apparatus has multiple Ubiquitin-binding domains and participates in a wide variety of cellular processes. Many of these ESCRT-dependent processes are keenly regulated by Ub, which serves as a lysosomal sorting signal for membrane proteins targeted into multivesicular bodies and which may serve as a mediator of viral budding from the cell surface. Hints that both ESCRTs and Ub work together in the processes such as cytokinesis, transcription, and autophagy are beginning to emerge. Here we explore the relationship between ESCRTs and Ub in MVB sorting and viral budding.
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