How ubiquitin functions with ESCRTs.

How ubiquitin functions with ESCRTs.
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DOI:
10.1111/j.1600-0854.2011.01242.x
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发表时间:
2011-10
期刊:
Traffic (Copenhagen, Denmark)
影响因子:
--
通讯作者:
Piper RC
Piper RC
中科院分区:
其他
文献类型:
--
作者:
Shields SB;Piper RC

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ESCRT仪器有多个泛素结合域,并参与各种各样的细胞过程。许多这些依赖escrt的过程都受到Ub的强烈调节,Ub作为针对多泡体的膜蛋白的溶酶体分选信号,并且可能作为病毒从细胞表面出芽的介质。escrt和Ub在细胞分裂、转录和自噬等过程中共同起作用的迹象开始出现。本研究探讨escrt与Ub在MVB分选和病毒出芽中的关系。
The ESCRT apparatus has multiple Ubiquitin-binding domains and participates in a wide variety of cellular processes. Many of these ESCRT-dependent processes are keenly regulated by Ub, which serves as a lysosomal sorting signal for membrane proteins targeted into multivesicular bodies and which may serve as a mediator of viral budding from the cell surface. Hints that both ESCRTs and Ub work together in the processes such as cytokinesis, transcription, and autophagy are beginning to emerge. Here we explore the relationship between ESCRTs and Ub in MVB sorting and viral budding.
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