Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep
Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep
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DOI：
10.1096/fj.08-122853
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发表时间：
2009-10-01
期刊：
影响因子：
4.8
通讯作者：
Marshall, Lisa
中科院分区：
文献类型：
--
作者：
Benedict, Christian;Scheller, Juergen;Marshall, Lisa
细胞因子IL-6被认为对大脑产生神经调节作用，并对睡眠产生促进作用。睡眠增强记忆的巩固，并且特别地，晚夜睡眠也代表增强的IL-6信号传导的时期，这是由于在此期间可溶性IL-6受体的显著增强的可用性，使得能够将IL-6的信号传导至神经元。因此，假设IL-6对睡眠依赖性记忆巩固的贡献。为了验证这一假设，我们比较了鼻内注射IL-6（与安慰剂）对17名健康年轻男性的陈述性（中性和情感文本，二维物体位置）和程序性（手指序列敲击）记忆的睡眠依赖性巩固的影响。IL-6可明显改善情绪文本材料的睡眠相关巩固（P
The cytokine IL-6 has been considered to exert neuromodulating influences on the brain, with promoting influences on sleep. Sleep enhances the consolidation of memories, and, in particular, late nocturnal sleep also represents a period of enhanced IL-6 signaling, due to a distinctly enhanced availability of soluble IL-6 receptors during this period, enabling trans-signaling of IL-6 to neurons. Thus, a contribution of IL-6 to sleep-dependent memory consolidation is hypothesized. To test this hypothesis, we compared effects of intranasally administered IL-6 (vs. placebo) on sleep-dependent consolidation of declarative (neutral and emotional texts, 2-dimensional object location) and procedural (finger sequence tapping) memories in 17 healthy young men. IL-6 distinctly improved the sleep-related consolidation of emotional text material (P