An automated self-similarity analysis of the pulmonary tree of the Sprague-Dawley rat.
An automated self-similarity analysis of the pulmonary tree of the Sprague-Dawley rat.
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DOI：
10.1002/ar.20771
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发表时间：
2008-12
影响因子：
2
通讯作者：
Corley, Richard A.
中科院分区：
文献类型：
--
作者：
Einstein, Daniel R.;Neradilak, Blazej;Pollisar, Nayak;Minard, Kevin R.;Wallis, Chris;Fanucchi, Michelle;Carson, James P.;Kuprat, Andrew P.;Kabilan, Senthil;Jacob, Richard E.;Corley, Richard A.
我们提出了一个自动化的分析结果的肺气道树的Sprague道利大鼠。我们的工作是出于需要通知低维数学模型，以规定现实的边界条件，大鼠肺力学的多尺度混合模型。将3只年龄匹配的雄性Sprague道利大鼠浸入含有造影剂的凝胶中，然后进行磁共振（MR）成像，制成硅胶模型。从该数据的分割中，我们提取了表示气道中心线的连接图。节段统计数据（长度和直径）来自该图。为了验证这种MR成像/数字分析方法，将气道段测量值与使用光学显微镜从大鼠肺铸型中手动收集的近一千个测量值进行比较。为了评价MR成像/数字分析方法的再现性，两个肺模型在MR孔中随机取向各成像三次。在每个重复成像数据集中比较随机选择的气道直径和长度，以估计变异性。最后，我们通过将单个气道段组装成跨越多代的结构（我们称之为分支）来分析气道树的形态学。我们发现，分支，而不是段是在大鼠肺的基本重复单元，并制定简单的数学关系，描述这些结构的整个肺。我们的分析表明，气道直径和长度具有确定性和随机性。
We present the results of an automated analysis of the morphometry of the pulmonary airway trees of the Sprague Dawley rat. Our work is motivated by a need to inform lower-dimensional mathematical models in order to prescribe realistic boundary conditions for multiscale hybrid models of rat lung mechanics. Silicone casts were made from three age-matched, male Sprague Dawley rats, immersed in a gel containing a contrast agent and subsequently imaged with magnetic resonance (MR). From a segmentation of this data, we extracted a connected graph, representing the airway centerline. Segment statistics (lengths and diameters) were derived from this graph. To validate this MR imaging/digital analysis method, airway segment measurements were compared to nearly one thousand measurements collected by hand using an optical microscope from one of the rat lung casts. To evaluate the reproducibility of the MR imaging/digital analysis method, two lung casts were each imaged three times with randomized orientations in the MR bore. Diameters and lengths of randomly selected airways were compared among each of the repeated imaging datasets to estimate the variability. Finally, we analyzed the morphometry of the airway tree by assembling individual airway segments into structures that span multiple generations, which we call branches. We show that branches not segments are the fundamental repeating unit in the rat lung and develop simple mathematical relationships describing these structures for the entire lung. Our analysis shows that airway diameters and lengths have both a deterministic and stochastic character.
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DOI：
10.1016/0034-5687(86)90033-2
发表时间：
1986-01-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
HORSFIELD, K;WOLDENBERG, MJ
通讯作者：
WOLDENBERG, MJ
DOI：
10.1152/ajpheart.00579.2005
发表时间：
2006-02-01
影响因子：
4.8
作者：
Kassab, GS
通讯作者：
Kassab, GS
影响因子：
3.8
作者：
Mautz, WJ;Kleinman, MT;Phalen, RF
通讯作者：
Phalen, RF
影响因子：
8.2
作者：
MENACHE, MG;PATRA, AL;MILLER, FJ
通讯作者：
MILLER, FJ
影响因子：
2.1
作者：
Moss, O. R.;Wong, V. A.
通讯作者：
Wong, V. A.