Neural changes with attention bias modification for anxiety: a randomized trial
Neural changes with attention bias modification for anxiety: a randomized trial
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DOI：
10.1093/scan/nsu141
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发表时间：
2015-07-01
影响因子：
4.2
通讯作者：
Bar-Haim, Yair
中科院分区：
文献类型：
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作者：
Britton, Jennifer C.;Suway, Jenna G.;Bar-Haim, Yair
注意偏倚矫正（ABM）治疗通常会减轻焦虑症状，但人们对与这种行为治疗相关的神经变化知之甚少。具有高度社交焦虑症状的健康成年人（n = 53）被随机分配接受活性或安慰剂ABM。与安慰剂ABM不同，主动ABM旨在训练个体的注意力，使其远离威胁。采用点探针任务，在急性训练和延长训练前后的磁共振成像中测量与威胁相关的注意偏倚。一部分参与者完成了所有程序（n = 30,15每组）。使用标准分析确定神经激活的组差异。线性回归检验症状减轻的预测因素（即训练组、威胁偏倚基线指数）。活跃组和安慰剂组在训练中表现出不同的左右杏仁核激活模式。在所有参与者中，无论小组，在训练前的威胁-偏见对比中，左侧杏仁核激活程度较高的个体表现出更大的症状减轻。考虑到基线杏仁核激活后，更大的症状减轻与分配到积极训练组有关。基线时左杏仁核更大的激活预示着ABM后社交焦虑症状的减少。需要进一步的研究来阐明与ABM训练相关的脑行为机制。
Attention bias modification (ABM) procedures typically reduce anxiety symptoms, yet little is known about the neural changes associated with this behavioral treatment. Healthy adults with high social anxiety symptoms (n = 53) were randomized to receive either active or placebo ABM. Unlike placebo ABM, active ABM aimed to train individuals' attention away from threat. Using the dot-probe task, threat-related attention bias was measured during magnetic resonance imaging before and after acute and extended training over 4 weeks. A subset of participants completed all procedures (n = 30, 15 per group). Group differences in neural activation were identified using standard analyses. Linear regression tested predictive factors of symptom reduction (i.e., training group, baseline indices of threat bias). The active and placebo groups exhibited different patterns of right and left amygdala activation with training. Across all participants irrespective of group, individuals with greater left amygdala activation in the threat-bias contrast prior to training exhibited greater symptom reduction. After accounting for baseline amygdala activation, greater symptom reduction was associated with assignment to the active training group. Greater left amygdala activation at baseline predicted reductions in social anxiety symptoms following ABM. Further research is needed to clarify brain-behavior mechanisms associated with ABM training.