Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress
Involvement of hippocampal serotonin and neuropeptide Y in depression induced by chronic unpredicted mild stress
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DOI：
10.1016/j.brainresbull.2008.05.010
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发表时间：
2008-09-05
影响因子：
3.8
通讯作者：
Zhang, X.
中科院分区：
文献类型：
--
作者：
Luo, D. D.;An, S. C.;Zhang, X.
积累的证据表明海马 5-羟色胺 (5-HT) 和神经肽 Y (NPY) 在应激反应和抑郁调节中发挥作用，但尚不清楚海马 5-HT 和 NPY 系统是否以及如何导致慢性不可预测的轻度应激 (CUMS) 诱发的抑郁。在这里，我们观察到，接受各种慢性不可预测的温和应激源3周的大鼠表现出多种抑郁样行为变化，包括体重显着降低、蔗糖偏好以及旷场试验中的运动、饲养和梳理行为，以及强迫游泳试验中不动时间的显着增加。这些 CUMS 诱导的行为变化可通过海马内注射 5-HT (31.25 μg/μl) 或 NPY (10 μg/μl) 得到抑制或阻断。这些数据表明海马 5-HT 和 NPY 神经传递减少在 CUMS 诱发的抑郁症中发挥着关键作用。 (C) 2008 Elsevier Inc. 保留所有权利。
Accumulated evidence indicates a role of the hippocampal 5-hydroxy-tryptamine (5-HT) and neuropeptide Y (NPY) in the response to stress and modulation of depression, but it is unclear whether and how the hippocampal 5-HT and NPY systems make contributions to chronic unpredicted mild stress (CUMS)-induced depression. Here we observed that rats receiving a variety of chronic unpredictable mild stressors for 3 weeks showed a variety of depression-like behavioral changes, including a significant reduction in body weight, sucrose preference, and locomotion, rearing and grooming in open field test, and a significant increase in immobility time in forced swimming test. These CUMS-induced behavioral changes were suppressed or blocked by intra-hippocampal injection of 5-HT (31.25 mu g/mu l) or NPY (10 mu g/mu l). These data suggest a critical role of reduced hippocampal 5-HT and NPY neurotransmission in CUMS-induced depression. (C) 2008 Elsevier Inc. All rights reserved.