P(NMe2)(3)-Mediated Aziridination of (mines with alpha-Ketoesters for Synthesis of Aziridine-2-carboxylates
P(NMe2)(3)-Mediated Aziridination of (mines with alpha-Ketoesters for Synthesis of Aziridine-2-carboxylates
复制标题
P(NMe2)(3)-介导的(矿与α-酮酯的氮丙啶化反应用于合成氮丙啶-2-羧酸酯
DOI：
10.1021/acs.joc.6b02669
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发表时间：
2017
影响因子：
3.6
通讯作者：
Xu Yan-Jun
中科院分区：
文献类型：
--
作者：
Jiang Jin;Liu Hui;Lu Chong-Dao;Xu Yan-Jun
报道了在P（NMe 2）3存在下N-磺酰亚胺与α-酮酯的氮杂环丙烷化反应。衍生自三价磷试剂和α-酮酯的加合物被亚胺有效拦截，得到一系列氮丙啶-2-羧酸盐。反应的非对映选择性取决于底物上取代基的空间位阻。
Aziridination ofN-sulfonyl imines with α-ketoesters in the presence of P(NMe2)3is reported. Adducts derived from trivalent phosphorus reagents and α-ketoesters are effectively intercepted by imines, affording a range of aziridine-2-carboxylates. The diastereoselectivity of the reaction depends on steric hindrance from substituents on the substrates.