Microbiome in Parturition and Preterm Birth
Microbiome in Parturition and Preterm Birth
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DOI：
10.1055/s-0033-1361830
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发表时间：
2014-01-01
影响因子：
2.7
通讯作者：
Cao, Bin
中科院分区：
文献类型：
--
作者：
Mysorekar, Indira U.;Cao, Bin
早产是全球性的母婴健康问题之一。近年来，关于微生物组作用的报道激增（即，微生物生物量）对过多的生理和病理人类状况的影响。这篇综述旨在描述我们目前对微生物组及其对分娩的影响的理解，特别强调早产。我们将重点关注阴道和口腔粘膜微生物组在早产中的作用，并描述微生物组研究中使用的最先进方法。接下来，我们将介绍关于胎盘中潜在微生物组的新研究，以及它如何影响妊娠结果。最后，我们将提出宿主遗传因素可以干扰正常的妊娠微生物组并引发不良妊娠结局。
Preterm parturition is a one of the most significant global maternal-child health problem. In recent years, there has been an explosion in reports on a role for microbiomes (i.e., a microbial biomass) on a plethora of physiologic and pathologic human conditions. This review aims to describe our current understanding of the microbiome and its impact on parturition, with particular emphasis on preterm birth. We will focus on the roles of vaginal and oral mucosal microbiomes in premature parturition and describe the state-of-the-art methodologies used in microbiome studies. Next, we will present new studies on a potential microbiome in the placenta and how it may affect pregnancy outcomes. Finally, we will propose that host genetic factors can perturb the normal pregnancy microbiome and trigger adverse pregnancy outcomes.