Dynamics of tremor-related oscillations in the human globus pallidus: A single case study
Dynamics of tremor-related oscillations in the human globus pallidus: A single case study
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DOI：
10.1073/pnas.96.4.1674
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发表时间：
1999-02-16
影响因子：
11.1
通讯作者：
Sigvardt, KA
中科院分区：
文献类型：
--
作者：
Hurtado, JM;Gray, CM;Sigvardt, KA
生理学证据表明，帕金森病的静止性震颤起源于前脑的振荡神经活动，但尚不清楚该活动是全局同步的还是由并行的、独立的振荡电路组成。在本研究中，我使用双微电极记录了一位接受立体定位苍白球切开术的清醒帕金森病患者苍白球内段 (GPi) 八个位点的与震颤相关的神经元活动。我利用频谱分析来评估空间分离部位的多单元活动之间以及神经和肢体肌电活动之间的时间相关性。我们观察到一些 GPi 神经对以震颤频率同步振荡，而其他神经对则独立振荡。此外，我们发现特定部位的 GPI 震颤相关活动可能在上肢震颤的同步状态和独立状态之间波动。与这一发现一致的是，GPi 内相同的配对记录位点显示出短暂同步的周期。这些观察结果支持独立震颤产生电路的假设，其耦合会随着时间的推移而波动。
Physiological evidence indicates that the resting tremor of Parkinson's disease originates in oscillatory neural activity in the forebrain, but it is unknown whether that activity is globally synchronized or consists of parallel, independently oscillating circuits. In the present study, me used dual microelectrodes to record tremor-related neuronal activity from eight sites in the internal segment of the globus pallidus (GPi) from an awake Parkinson's disease patient undergoing stereotaxic pallidotomy. me utilized spectral analysis to evaluate the temporal correlations between multiunit activity at spatially separated sites and between neural and limb electromyographic activity. We observed that some GPi neural pairs oscillated synchronously at the tremor frequency, whereas other neural pairs oscillated independently. Additionally, we found that GPI tremor-related activity at a given site could fluctuate between states of synchronization and independence with respect to upper limb tremor. Consistent with this finding, same paired recording sites within GPi showed periods of transient synchronization. These observations support the hypothesis of independent tremor-generating circuits whose coupling can fluctuate over time.