Copper-Catalyzed Oxidative Self-Coupling of -Amino Carbonyl Compounds for the Synthesis of Tetrasubstituted 1,4-Enediones
Copper-Catalyzed Oxidative Self-Coupling of -Amino Carbonyl Compounds for the Synthesis of Tetrasubstituted 1,4-Enediones
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铜催化氨基羰基化合物氧化自偶联合成四取代 1,4-烯二酮
DOI：
10.1055/s-0037-1611227
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发表时间：
2018
期刊：
影响因子：
2
通讯作者：
Xiang Jiannan
中科院分区：
文献类型：
--
作者：
Yia Niannian;Xiong Yi;Huang Qingjun;Yan Ning;Xie Yanjun;Lan Donghui;Yi Ziqi;Au Chak-Tong;Yi Bing;Xiang Jiannan
发展了一种铜催化的α-氨基羰基化合物的氧化自偶联反应，通过α-氨基羰基化合物中4个sp3 C-H键的断裂和1个C=C双键的同时形成，以中等至良好的产率合成了四取代的1，4-烯二酮（Z-异构体）。该方法具有原料易得、立体选择性高等优点。
A protocol for the copper-catalyzed oxidative self-coupling of α-amino carbonyl compounds has been developed for the synthesis of tetrasubstituted 1,4-enediones (Z-isomers) in moderate to good yields through the cleavage of four sp3C–H bonds and the simultaneous formation of one C=C double bond in the α-amino carbonyl compound. The strategy has the advantages of using readily available starting materials and of high stereoselectivity.