DNA‐Based Chemical Reaction Networks
DNA‐Based Chemical Reaction Networks
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DOI：
10.1002/cbic.201800721
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发表时间：
2019-05
期刊：
影响因子：
3.2
通讯作者：
Fan Li;M. Xiao;H. Pei
中科院分区：
文献类型：
--
作者：
Fan Li;M. Xiao;H. Pei
在生物有机体复杂的分子网络的推动下，人工化学反应网络的自下而上的发展重新引起了生物化学家的兴趣。基于DNA的化学反应网络(D-CRN)以其高度的可编程性和方向性为基础，基于杂交和链置换反应，为描述和分析(生物)化学系统提供了一种很有前途的方法。在此，讨论了D-CRN的发展进展，并概述了近几十年来报道的基于D-CRN的重要生物化学应用。此外，还讨论了D-CRN在生物化学中的研究机会和未来的发展方向。
Motivated by complex molecular networks of biological organisms, which enable control of the temporal and spatial concentrations of molecules, the bottom‐up development of artificial chemical reaction networks has received renewed interest from biochemists. Based on hybridization and strand‐displacement reactions, DNA‐based chemical reaction networks (D‐CRNs) provide a promising method to describe and analyze (bio)chemical systems, depending on their high programmability and directionality. Herein, progress in the development of D‐CRNs is discussed, and an overview of significant biochemistry applications based on D‐CRNs reported in recent decades is provided. Furthermore, opportunities and future directions for research into D‐CRNs in biochemistry are also discussed.