A novel three-dimensional scaffold for regenerative endodontics: materials and biological characterizations
A novel three-dimensional scaffold for regenerative endodontics: materials and biological characterizations
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DOI：
10.1002/term.1712
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发表时间：
2015-11-01
影响因子：
3.3
通讯作者：
Bressiani, Ana H. A.
中科院分区：
文献类型：
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作者：
Bottino, Marco C.;Yassen, Ghaeth H.;Bressiani, Ana H. A.
一种电纺纳米复合纤维材料有望成为一种支架，以及一种药物输送装置，有助于牙根成熟发生和牙髓-牙本质复合体的再生。采用静电纺丝法设计并制备了聚二氧环酮（PDS II (R)）和高岭土纳米管（HNTs）组成的三维纳米复合支架。形态学、结构、力学性能和细胞相容性研究来评估HNTs掺入的效果（0.5-10wt%相对于PDS w/w）。总体而言，无论HNT含量如何，在不同制备的电纺丝支架中都可以看到3D多孔网络。在10wt%时加入hnt导致显著的(p
An electrospun nanocomposite fibrous material holds promise as a scaffold, as well as a drug-delivery device to aid in root maturogenesis and the regeneration of the pulp-dentine complex. A novel three-dimensional (3D) nanocomposite scaffold composed of polydioxanone (PDS II (R)) and halloysite nanotubes (HNTs) was designed and fabricated by electrospinning. Morphology, structure, mechanical properties and cell compatibility studies were carried out to evaluate the effects of HNTs incorporation (0.5-10wt% relative to PDS w/w). Overall, a 3D porous network was seen in the different fabricated electrospun scaffolds, regardless of the HNT content. The incorporation of HNTs at 10wt% led to a significant (p