A cascade reaction network mimicking the basic functional steps of adaptive immune response.
A cascade reaction network mimicking the basic functional steps of adaptive immune response.
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模仿适应性免疫反应基本功能步骤的级联反应网络
DOI：
10.1038/nchem.2325
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发表时间：
2015-10
期刊：
影响因子：
21.8
通讯作者：
Tan W
中科院分区：
文献类型：
--
作者：
Han D;Wu C;You M;Zhang T;Wan S;Chen T;Qiu L;Zheng Z;Liang H;Tan W
生物系统使用由分子网络组成的复杂的“信息处理核心”来协调其外部环境和内部状态。获得性或获得性免疫系统(AIS)就是一个例子，它由体液和细胞介导的成分组成。在这里，我们报告了一个模仿AIS的原型的逐步构建，我们称之为适应性免疫反应模拟器(AIRS)。DNA和酶被用作AIS组件的简单人工类似物，以创建一个在体外对特定分子刺激做出反应的系统。我们表明，这个反应网络可以以一种表面上类似于脊椎动物AIS最基本反应的方式发挥作用，包括模仿体液和细胞反应的反应序列。因此，AIRS为人工反应网络和分子装置的设计和工程提供了指南。本文的在线版本(doi：10.1038/nChem.2325)包含补充材料，授权用户可以使用。已经建立了一个级联反应网络，其功能表面上类似于脊椎动物适应性免疫反应的最基本步骤。这个反应网络使用DNA和酶作为后天免疫系统各组成部分的简单人工类似物。本文的在线版本(doi：10.1038/nChem.2325)包含补充材料，授权用户可以使用。
Biological systems use complex ‘information-processing cores’ composed of molecular networks to coordinate their external environment and internal states. An example of this is the acquired, or adaptive, immune system (AIS), which is composed of both humoral and cell-mediated components. Here we report the step-by-step construction of a prototype mimic of the AIS that we call an adaptive immune response simulator (AIRS). DNA and enzymes are used as simple artificial analogues of the components of the AIS to create a system that responds to specific molecular stimuli in vitro. We show that this network of reactions can function in a manner that is superficially similar to the most basic responses of the vertebrate AIS, including reaction sequences that mimic both humoral and cellular responses. As such, AIRS provides guidelines for the design and engineering of artificial reaction networks and molecular devices. The online version of this article (doi:10.1038/nchem.2325) contains supplementary material, which is available to authorized users. A cascade reaction network has been created that can function in a manner that is superficially similar to the most basic steps of the vertebrate adaptive immune response. This reaction network uses DNA and enzymes as simple artificial analogues of the components of the acquired immune system. The online version of this article (doi:10.1038/nchem.2325) contains supplementary material, which is available to authorized users.