On the control of acute rodent malaria infections by innate immunity.
On the control of acute rodent malaria infections by innate immunity.
复制标题
DOI：
10.1371/journal.pone.0010444
复制
发表时间：
2010-05-06
期刊：
影响因子：
3.7
通讯作者：
Antia R
中科院分区：
文献类型：
--
作者：
Kochin BF;Yates AJ;de Roode JC;Antia R
特异性免疫、先天免疫或资源（红细胞）限制是否控制急性啮齿动物疟疾感染中血液期寄生虫的第一个高峰？由于特异性免疫缺陷的小鼠表现出与野生型小鼠相似的初始动力学，因此通常认为寄生虫的初始控制是由于资源（RBC）的限制或先天免疫应答。关于这两种机制的作用存在相互冲突的观点，因为有实验证据支持这两种假设。虽然基于RBC限制的数学模型能够描述原发性感染的动态，但尚不清楚结合先天免疫关键特征的模型是否能够做到这一点。我们研究的条件下，将寄生虫和先天免疫模型可以描述的数据，从急性夏氏疟原虫感染小鼠。我们发现，先天免疫反应必须衰减缓慢，如果寄生虫密度下降，而不是平衡。此外，我们表明，在这个框架内的动态的两种寄生虫菌株的差异最好归因于先天免疫的易感性的差异，而不是菌株的生长速度或其倾向引起先天免疫的差异。我们认为，需要进一步的工作，以确定是否先天免疫或资源限制控制急性疟疾感染的小鼠。
Does specific immunity, innate immunity or resource (red blood cell) limitation control the first peak of the blood-stage parasite in acute rodent malaria infections? Since mice deficient in specific immunity exhibit similar initial dynamics as wild-type mice it is generally viewed that the initial control of parasite is due to either limitation of resources (RBC) or innate immune responses. There are conflicting views on the roles of these two mechanisms as there is experimental evidence supporting both these hypotheses. While mathematical models based on RBC limitation are capable of describing the dynamics of primary infections, it was not clear whether a model incorporating the key features of innate immunity would be able to do the same. We examine the conditions under which a model incorporating parasite and innate immunity can describe data from acute Plasmodium chabaudi infections in mice. We find that innate immune response must decay slowly if the parasite density is to fall rather than equilibrate. Further, we show that within this framework the differences in the dynamics of two parasite strains are best ascribed to differences in susceptibility to innate immunity, rather than differences in the strains' growth rates or their propensity to elicit innate immunity. We suggest that further work is required to determine if innate immunity or resource limitation control acute malaria infections in mice.
登录
查看更多内容
疟疾感染的宿主控制：对免疫和红细胞反应动力学的限制。
影响因子：
4.3
作者：
McQueen, Philip G.;McKenzie, F. Ellis
通讯作者：
McKenzie, F. Ellis
影响因子：
3.1
作者：
STEVENSON, MM;TAM, MF;PODOBA, JE
通讯作者：
PODOBA, JE
DOI：
10.1073/pnas.0500078102
发表时间：
2005-05-24
影响因子：
11.1
作者：
de Roode, JC;Pansini, R;Read, AF
通讯作者：
Read, AF
影响因子：
2.9
作者：
Mideo, Nicole;Barclay, Victoria C.;Day, Troy
通讯作者：
Day, Troy
影响因子：
64.8
作者：
Roberts, D J;Craig, A G;Berendt, A R;Pinches, R;Nash, G;Marsh, K;Newbold, C I
通讯作者：
Newbold, C I