An analysis of geographic and intersexual chemical variation in venoms of the spider Tegenaria agrestis (Agelenidae)
An analysis of geographic and intersexual chemical variation in venoms of the spider Tegenaria agrestis (Agelenidae)
复制标题
DOI：
10.1016/s0041-0101(00)00234-8
复制
发表时间：
2001-07-01
期刊：
影响因子：
2.8
通讯作者：
Binford, GJ
中科院分区：
文献类型：
--
作者：
Binford, GJ
蜘蛛Tegenaria agrestis原产于欧洲，在那里它被认为是医学上无害的。这个物种最近在美国定居，在那里它被指控咬伤导致坏死病变和对人类的全身影响。一种可能的解释是美国蜘蛛有独特的毒液特征。这项研究比较了来自美国和欧洲种群的整个毒液，以寻找独特的美国特征，并增加我们对物种内毒液变异的理解。本文采用液相色谱法对美国华盛顿Marysville、英国Tungstead Quarry和瑞士Le Landeron的三种不同产地的野田鼠雌雄毒液进行了比较；以及美国和英国人口的昆虫生物测定。在美国和英国人群中，色谱图谱在两性之间是不同的，但在两性之间是相似的。瑞士人口的毒液在成分上与英国和美国的毒液略有不同。没有美国人口独有的峰值。两性间差异主要表现在组分的相对丰度上。昆虫分析显示，美国和英国的毒液效力没有差异，但雌性毒液比雄性毒液更有效。这些结果很难与坏死性作用的说法相一致，坏死性作用是美国蛇毒所特有的。2001爱思唯尔科学有限公司版权所有。
The spider Tegenaria agrestis is native to Europe, where it is considered medically innocuous. This species recently colonized the US where it has been accused of bites that result in necrotic lesions and systemic effects in humans. One possible explanation of this pattern is the US spiders have unique venom characteristics. This study compares whole venoms from US and European populations to look for unique US characteristics, and to increase our understanding of venom variability within species. This study compared venoms from T. agrestis males and females from Marysville, Washington (US), Tungstead Quarry, England (UK) and Le Landeron, Switzerland, by means of liquid chromatography; and the US and UK populations by insect bioassays. Chromatographic profiles were different between sexes, but similar within sexes between US and UK populations. Venoms from the Swiss population differed subtly in composition from UK and US venoms. No peaks were unique to the US population. Intersexual differences were primarily in relative abundance of components. Insect assays revealed no differences between US and UK venom potency, but female venoms were more potent than male. These results are difficult to reconcile with claims of necrotic effects that are unique to venoms of US Tegenaria. (C) 2001 Elsevier Science Ltd. All rights reserved.