Nerve growth factor concentration in human saliva
Nerve growth factor concentration in human saliva
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DOI：
10.1111/j.1601-0825.2006.01265.x
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发表时间：
2007-03-01
期刊：
影响因子：
3.8
通讯作者：
Kim, Y-K
中科院分区：
文献类型：
--
作者：
Nam, J-W;Chung, J-W;Kim, Y-K
目的：本研究的目的是测量正常浓度的神经生长因子（NGF）在健康人唾液中，并探讨年龄和性别差异对唾液神经生长因子level.MATERIALS和METHODS的影响：从127名健康志愿者，年龄从20岁到81岁的休息的整体，刺激腮腺，刺激下颌下/舌下唾液收集。结果和结论：唾液中NGF的平均浓度分别为901.4 ± 75.6 pg ml（-1），885.9 ± 79.9 pg ml（-1），1066.1 ± 88.1 pg ml（-1）。刺激的下颌下腺唾液中的NGF浓度随年龄的增长而降低（rho =-0.296，P = 0.001）。女性静息全唾液（P = 0.025）和刺激腮腺唾液（P = 0.005）的NGF浓度显著高于男性。刺激下颌下腺唾液中的NGF浓度显著高于刺激腮腺唾液（P = 0.005），并与刺激腮腺唾液中的NGF水平显著相关（rho =-0.244，P = 0.008）。我们发现在所有三个来源的唾液中的NGF的浓度可测量的浓度，浓度受刺激腮腺和下颌下唾液的来源，年龄刺激下颌下唾液，和性别差异的休息全唾液和刺激腮腺唾液。
OBJECTIVE: The aims of this study were to measure the normal concentration of nerve growth factor (NGF) in healthy human saliva and to investigate the effects of age and gender differences on saliva NGF level.MATERIALS AND METHODS: Resting whole, stimulated parotid, and stimulated submandibular/sublingual saliva were collected from 127 healthy volunteers with ages ranging from 20 to 81 years. The saliva NGF concentration was measured by enzyme immunoassay.RESULTS AND CONCLUSIONS: The mean concentrations of NGF were 901.4 +/- 75.6 pg ml(-1) in resting whole saliva, 885.9 +/- 79.9 pg ml(-1) in stimulated parotid saliva, and 1066.1 +/- 88.1 pg ml(-1) in stimulated submandibular/sublingual saliva. The stimulated submandibular saliva showed lower NGF concentrations with increasing age (rho = -0.296, P = 0.001). The NGF concentrations of resting whole saliva (P = 0.025) and stimulated parotid saliva (P = 0.005) were significantly higher in women than men. The NGF concentration of stimulated submandibular saliva was significantly higher than stimulated parotid saliva (P = 0.005) and significantly correlated with stimulated parotid saliva NGF level (rho = -0.244, P = 0.008). We found measurable concentrations of NGF in all three sources of saliva; the concentration was affected by the source for the stimulated parotid and submandibular saliva, age for stimulated submandibular saliva, and gender difference for resting whole saliva and stimulated parotid saliva.