Leptin concentrations in women in the San Antonio Heart Study: effect of menopausal status and postmenopausal hormone replacement therapy.
Leptin concentrations in women in the San Antonio Heart Study: effect of menopausal status and postmenopausal hormone replacement therapy.
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圣安东尼奥心脏研究中女性瘦素浓度：绝经状态和绝经后激素替代疗法的影响。
DOI：
10.1093/oxfordjournals.aje.a009317
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发表时间：
1997
影响因子：
5
通讯作者：
Stern,MP
中科院分区：
文献类型：
--
作者：
Haffner,SM;Mykkänen,L;Stern,MP
瘦素，人类肥胖基因的产物，在肥胖个体中增加，表明对它的作用有抵抗力。然而，在每个体重指数水平的瘦素水平存在变异性，这表明遗传和环境因素而不是整体肥胖可能调节瘦素浓度。女性瘦素浓度高于男性，这种差异只能部分解释为女性脂肪库增加。作者推测，女性体内较高的雌激素水平可能是瘦素浓度两性异形的原因。为了验证这一假设，他们在圣安东尼奥心脏研究中测量了未服用口服避孕药（PRE）的绝经前妇女（n= 53），服用激素替代疗法（POSTY）的绝经后妇女（n= 28）和未服用激素替代疗法（POSTY）的绝经后妇女（n= 28）的瘦素浓度。分析仅限于非糖尿病的墨西哥裔美国人。根据体重指数（kg/m2）评估，受试者在肥胖方面匹配良好：PRE = 31.0，POSTY = 29.8，POSTY = 31.6。三组间瘦素浓度（ng/ml）无显著差异（PRE = 27.6，POSTY = 28.3，POSTY = 27.8）。作者得出结论，雌激素水平的差异不太可能解释瘦素浓度的两性异形。
Leptin, the product of the humanOBgene, is increased in obese individuals, suggesting resistance to its effect. However, there is variability in leptin levels at each level of body mass index, suggesting that genetic and environmental factors other than overall adiposity may regulate leptin concentrations. Leptin concentrations are higher in women relative to men, a difference that is only partially explained by the increased fat depots in women. The authors hypothesized that higher estrogen levels in women might be responsible for the sexual dimorphism in leptin concentrations. To test this hypothesis, they measured leptin concentrations in premenopausal women not on oral contraceptives (PRE) (n= 53), postmenopausal women on hormone replacement therapy (POSTY) (n= 28), and postmenopausal women not on hormone replacement therapy (POSTN) (n= 28) in the San Antonio Heart Study, a population-based study of diabetes and cardiovascular risk factors. Analyses were restricted to nondiabetic Mexican Americans. Subjects were well matched on obesity as assessed by body mass index (kg/m2): PRE = 31.0, POSTY = 29.8, and POSTN = 31.6. Leptin concentrations (ng/ml) were not significantly different among the three groups (PRE = 27.6, POSTY = 28.3, and POSTN = 27.8). The authors conclude that differences in estrogen levels are not likely to explain the sexual dimorphism in leptin concentrations.
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