Interspecies differences in bone composition, density, and quality:: Potential implications for in vivo bone research
Interspecies differences in bone composition, density, and quality:: Potential implications for in vivo bone research
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DOI：
10.1210/en.139.2.663
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发表时间：
1998-02-01
期刊：
影响因子：
4.8
通讯作者：
Dequeker, J
中科院分区：
文献类型：
--
作者：
Aerssens, J;Boonen, S;Dequeker, J
本研究比较了骨骼研究中常用的七种脊椎动物（人、狗、猪、牛、羊、鸡和大鼠）的骨骼样本的骨骼成分、密度和质量。分析了皮质股骨样品的灰分、胶原蛋白、可提取蛋白质和胰岛素样生长因子-I 的含量。这些参数也在根据骨颗粒密度分离后获得的骨粉级分中进行测量。所有分析中均观察到较大的种间差异。在生化分析中包括的所有物种中，大鼠骨骼的差异最大，而犬骨骼与人类骨骼最相似。此外，对圆柱形小梁骨芯进行了骨密度和机械测试分析。两项分析均表明存在较大的种间差异。人体样本中骨密度和骨折应力值最低；猪骨和犬骨与这些样本最为相似。骨密度对骨机械能力的相对贡献很大程度上取决于物种。总之，此处报告的数据表明，在其他临床和实验骨参数中可能会发现种间差异，因此在选择合适的动物模型进行骨研究时应考虑到。
This study compares bone composition, density, and quality in bone samples derived from seven vertebrates that are commonly used in bone research: human, dog, pig, cow, sheep, chicken, and rat. Cortical femoral bone samples were analyzed for their content of ash, collagen, extractable proteins, and insulin-like growth factor-I. These parameters were also measured in bone powder fractions that were obtained after separation of bone particles according to their density. Large interspecies differences were observed in all analyses. Of all species included in the biochemical analyses, rat bone was most different, whereas canine bone best resembled human bone. In addition, bone density and mechanical testing analyses were performed on cylindrical trabecular bone cores. Both analyses demonstrated large interspecies variations. The lowest bone density and fracture stress values were found in the human samples; porcine and canine bone best resembled these samples. The relative contribution of bone density to bone mechanical competence was largely species-dependent. Together, the data reported here suggest that interspecies differences are likely to be found in other clinical and experimental bone parameters and should therefore be considered when choosing an appropriate animal model for bone research.