Updated overview of current biomarkers in head and neck carcinoma.
Updated overview of current biomarkers in head and neck carcinoma.
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DOI：
10.5662/wjm.v6.i1.77
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发表时间：
2016-03-26
期刊：
影响因子：
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通讯作者：
Dhankhar, Rakesh
中科院分区：
文献类型：
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作者：
Dahiya, Kiran;Dhankhar, Rakesh
鳞状细胞癌是头颈部上皮细胞最常见的恶性肿瘤。头颈部鳞状细胞癌（HNSCC）是世界范围内癌症相关伤亡的主要原因之一。随着治疗方式的进步，本病的总体预后得到一定程度的改善，但早期发现原发肿瘤和预防复发是进一步提高患者生存率的主要目标。关于该疾病分子特征的最新基础研究成果有助于更好地了解HNSCC进展的分子机制，以及识别和靶向与HNSCC相关的各种分子生物标志物。在本文中，我们回顾了最新的和潜在的早期检测HNSCC的生物标志物的信息。最终，详细的分子表征可能会改善新的治疗策略的发展，可能与头颈癌的诊断和预后相关。对更准确和及时的疾病预测的需求在这一领域产生了巨大的研究兴趣。
Squamous cell cancer is the most common type of malignancy arising from the epithelial cells of the head and neck region. Head and neck squamous cell carcinoma (HNSCC) is one of the predominant causes of cancer related casualties worldwide. Overall prognosis in this disease has improved to some extent with the advancements in therapeutic modalities but detection of primary tumor at its initial stage and prevention of relapse are the major targets to be achieved for further improvement in terms of survival rate of patients. Latest achievements in basic research regarding molecular characterization of the disease has helped in better perception of the molecular mechanisms involved in HNSCC progression and also in recognizing and targeting various molecular biomarkers associated with HNSCC. In the present article, we review the information regarding latest and potential biomarkers for the early detection of HNSCC. A detailed molecular characterization, ultimately, is likely to improve the development of new therapeutic strategies, potentially relevant to diagnosis and prognosis of head and neck cancers. The need for more accurate and timely disease prediction has generated enormous research interests in this field.