IMMOBILIZED-LIPOSOME CHROMATOGRAPHIC ANALYSIS OF DRUG PARTITIONING INTO LIPID BILAYERS
IMMOBILIZED-LIPOSOME CHROMATOGRAPHIC ANALYSIS OF DRUG PARTITIONING INTO LIPID BILAYERS
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DOI：
10.1016/0021-9673(95)00214-8
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发表时间：
1995-06-09
影响因子：
4.1
通讯作者：
LUNDAHL, P
中科院分区：
文献类型：
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作者：
BEIGI, F;YANG, Q;LUNDAHL, P
药物在凝胶床上与固定化脂质体的色谱阻滞被证明与药物通过上皮细胞层的吸收相关，这与药物分配到细胞膜的脂质双层有关。将容量因子除以凝胶床中的脂质浓度（mM）以获得比容量因子K-s。辛醇-水分配比的对数与log K-s呈线性相关，而上皮细胞单层中表观渗透系数的对数和人体口服给药药物的吸收（来自其他实验室的数据）在0
The chromatographic retardation of drugs on a gel bed with immobilized liposomes was shown to correlate with the absorption of the drugs through epithelial cell layers, which is related to drug partitioning into the lipid bilayers of cell membranes. The capacity factors were divided by the lipid concentration (mM) in the gel bed to obtain specific capacity factors, K-s. The logarithm of the octanol-water distribution ratios showed a linear correlation with log K-s, whereas the logarithm of the apparent permeability coefficients in epithelial cell monolayers and the absorption of drugs orally administered in humans (data from other laboratories) increased over the interval 0