Analysis of the genes activated by the FL08 gene in Saccharomyces cerevisiae
Analysis of the genes activated by the FL08 gene in Saccharomyces cerevisiae
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DOI：
10.1007/s002940050498
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发表时间：
1999-11-01
期刊：
影响因子：
2.5
通讯作者：
Sone, H
中科院分区：
文献类型：
--
作者：
Kobayashi, O;Yoshimoto, H;Sone, H
在酿酒酵母中，FLO8基因编码优势絮凝基因FLO1的转录激活子。为了确定其他受FLO8调控的基因，我们对FLO8和Delta FLO8菌株的转录本进行了详细的比较。研究发现，除FLO1基因外，FLO11和STA1基因的转录也受FLO8正向调控。在FLO8菌株中，不仅没有检测到FLO11、STA1和FLO1基因的转录本，而且没有检测到侵袭性生长、胞外糖淀粉酶的产生和絮凝。这些结果表明，FLO8通过转录调控FLO11、STA1和FLO1基因来调节这些特性。
It is thought that the FLO8 gene encodes a transcriptional activator of the dominant flocculation gene FLO1 in Saccharomyces cerevisiae. To determine other genes which are regulated by FLO8, a detailed comparison of the transcripts from the FLO8 and Delta flo8 strains was carried out. In addition to the FLO1 gene, it was found that transcription of the FLO11 and STA1 genes is positively regulated by FLO8. In flo8 strains, not only transcripts of the FLO11, STA1, and FLO1 genes but also invasive growth, extracellular glucoamylase production, and flocculation were undetected. From these results, it is suggested that FLO8 regulates these characteristics via the transcriptional regulation of the FLO11, STA1, and FLO1 genes.