Theta oscillations orchestrate medial temporal lobe and neocortex in remembering autobiographical memories
Theta oscillations orchestrate medial temporal lobe and neocortex in remembering autobiographical memories
复制标题
DOI：
10.1016/j.neuroimage.2013.08.029
复制
发表时间：
2014-01-15
期刊：
影响因子：
5.7
通讯作者：
Levine, B.
中科院分区：
文献类型：
--
作者：
Fuentemilla, L.;Barnes, G. R.;Levine, B.
回忆自传体事件可以与详细的视觉意象相关联。内侧颞叶（MTL）、楔前叶和前额叶皮层被认为共同实现了这种生动的回忆，但这些区域是如何协调的仍然不清楚。动物生理学的一个有影响力的预测是，θ频率的神经振荡可能很重要。在这个实验中，参与者前瞻性地收集了2到7个月内描述个人自传情节或语义知识的录音。当用脑磁图（MEG）记录大脑活动时，这些作为记忆提取线索被重放。我们确定了一个峰值的theta功率内的左MTL感兴趣的区域在自传体和一般语义检索。这亩，区域选择性相位同步与θ振荡楔前叶和内侧前额叶皮层，这种同步性较高，在自传体相比，一般语义知识检索。更高的同步性也预测更详细的视觉图像在检索。因此，当生动地回忆自传体经历时，θ相位同步协调人类MTL与分布式新皮层记忆网络。(C)2013 Elsevier Inc. All rights reserved.
Remembering autobiographical events can be associated with detailed visual imagery. The medial temporal lobe (MTL), precuneus and prefrontal cortex are held to jointly enable such vivid retrieval, but how these regions are orchestrated remains unclear. An influential prediction from animal physiology is that neural oscillations in theta frequency may be important. In this experiment, participants prospectively collected audio recordings describing personal autobiographical episodes or semantic knowledge over 2 to 7 months. These were replayed as memory retrieval cues while recording brain activity with magnetoencephalography (MEG). We identified a peak of theta power within a left MTL region of interest during both autobiographical and General Semantic retrieval. This mu, region was selectively phase-synchronized with theta oscillations in precuneus and medial prefrontal cortex, and this synchrony was higher during autobiographical as compared to General Semantic knowledge retrieval. Higher synchrony also predicted more detailed visual imagery during retrieval. Thus, theta phase-synchrony orchestrates in humans the MTL with a distributed neocortical memory network when vividly remembering autobiographical experiences. (C) 2013 Elsevier Inc. All rights reserved.