Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-β38/40/42 in Frontotemporal Dementias and Primary Progressive Aphasias
Cerebrospinal Fluid Tau, p-Tau 181 and Amyloid-β38/40/42 in Frontotemporal Dementias and Primary Progressive Aphasias
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DOI：
10.1159/000322370
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发表时间：
2011-01-01
影响因子：
2.4
通讯作者：
Wiltfang, Jens
中科院分区：
文献类型：
--
作者：
Bibl, Mirko;Mollenhauer, Brit;Wiltfang, Jens
背景/目的：我们测定了脑脊液（CSF）中淀粉样蛋白-β（Aβ）（1-38）、Aβ（1-40）、Aβ（1-42）、总tau和磷酸tau（p-tau）的浓度，以研究它们在额颞叶痴呆（FTD，n = 25）和原发性进行性失语（PPA，n = 12）中的差异表达，并与阿尔茨海默氏痴呆（AD，n = 25）和非痴呆对照（n = 20）。方法：采用市售的ELISA和电化学发光方法。结果：高 CSF p-tau 和低 A beta(1-42)/A beta(1-40) 和 A beta(1-42)/A beta(1-38) 比率分别对 AD 具有特异性。与其他每个诊断组（包括 PPA）相比，FTD 中的 CSF A beta(1-38) 有所减少。与 FTD 相比，PPA 中的 CSF tau 和 p-tau 水平升高。结论：这是第一份关于 PPA 生物标志物模式的详细报告，表明 FTD 和 PPA 中不同的 CSF 生物标志物模式是额颞叶变性的主要亚组。我们的结果的诊断和病理生理学意义值得对更大的神经病理学诊断的患者群体进行进一步研究。版权所有 (C) 2010 S. Karger AG，巴塞尔
Background/Aims: We determined cerebrospinal fluid (CSF) concentrations of amyloid-beta(A beta)(1-38), A beta(1-40), A beta(1-42), total tau and phospho-tau (p-tau) in order to study their differential expression in frontotemporal dementia (FTD, n = 25) and primary progressive aphasia (PPA, n = 12) as compared to Alzheimer's dementia (AD, n = 25) and nondemented controls (n = 20). Methods: Commercially available ELISA and electrochemiluminescence methods were applied. Results: High CSF p-tau and low ratios of A beta(1-42)/A beta(1-40) and A beta(1-42)/A beta(1-38), respectively, were specific for AD. CSF A beta(1-38) was reduced in FTD as compared to each of the other diagnostic groups, including PPA. CSF tau and p-tau levels were elevated in PPA as compared to FTD. Conclusion: This is the first detailed report on biomarker patterns in PPA, indicating distinct CSF biomarker patterns in FTD and PPA as major subgroups of frontotemporal lobar degeneration. The diagnostic and pathophysiological implications of our results warrant further studies on larger and neuropathologically diagnosed patient populations. Copyright (C) 2010 S. Karger AG, Basel