Sterically congested "roofed" 2-iminothioethers as new chiral ligands for palladium-catalyzed asymmetric allylic alkylation
Sterically congested "roofed" 2-iminothioethers as new chiral ligands for palladium-catalyzed asymmetric allylic alkylation
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DOI：
10.3987/com-05-s(k)50
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发表时间：
2005-12
期刊：
影响因子：
0.6
通讯作者：
Ryoh Tokuda;H. Matsunaga;T. Ishizuka;M. Nakajima;T. Kunieda
中科院分区：
文献类型：
--
作者：
Ryoh Tokuda;H. Matsunaga;T. Ishizuka;M. Nakajima;T. Kunieda
报道了一类新的具有空间拥挤、构象刚性的手性2-噻唑烷酮衍生物的合成。在碳酸铯碱存在下，该化合物可作为手性配体用于钯催化的1，3-二苯基-2-丙烯基乙酸酯与丙二酸二甲酯的不对称烯丙基烷基化反应。
The preparation of a new class of "roofed" aminothiol derivatives, from sterically congested, conformationally rigid chiral 2-thiazolidinones is described. The compounds function as efficient chiral ligands for the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate in the presence of cesium carbonate as a base.