Application of scanning acoustic microscopy for assessing stress distribution in atherosclerotic plaque
Application of scanning acoustic microscopy for assessing stress distribution in atherosclerotic plaque
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DOI：
10.1114/1.1424912
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发表时间：
2001-12-01
影响因子：
3.8
通讯作者：
Nitta, SI
中科院分区：
文献类型：
--
作者：
Saijo, Y;Ohashi, T;Nitta, SI
配备扫描声学显微镜（SAM）来评估正常和动脉粥样硬化冠状动脉的声学特性。动脉粥样硬化病变的SAM图像清楚地显示了声速高于正常内膜，并发现了弹性的变化，在纤维帽的斑块。计算每个区域的杨氏弹性模量，并应用有限元分析来获得这些动脉壁中的应力分布。在正常冠状动脉的情况下，应力主要集中在内膜中，分布相当均匀，在动脉粥样硬化的情况下，高应力集中在相对较软的病变的纤维帽覆盖脂质池。SAM提供了光学显微镜无法获得的物理性质信息。这一结果有助于进一步了解动脉粥样硬化的病理特征。(C)2001生物医学工程学会。
Scanning acoustic microscopy (SAM) was equipped to assess the acoustic properties of normal and atherosclerotic coronary arteries. The SAM image in the atherosclerotic lesion clearly demonstrated that the sound speed was higher than that in the normal intima, and that the variation of elasticity was found within the fibrous cap of the plaque. Young's elastic modulus of each region was calculated and the finite element analysis was applied to derive the stress distribution in these arterial walls. In a case of normal coronary artery, the stress was dominant in the intima and the distribution was rather homogeneous and in a case of atherosclerosis, high stress was concentrated to the relatively soft lesion in the fibrous cap overlying lipid pool. SAM provides information on the physical properties, which cannot be obtained by the optical microscope. The results would help in understanding the pathological features of atherosclerosis. (C) 2001 Biomedical Engineering Society.