Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder
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DOI：
10.1016/s0006-3223(01)01080-0
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发表时间：
2001-05-01
影响因子：
10.6
通讯作者：
Selemon, LD
中科院分区：
文献类型：
--
作者：
Rajkowska, G;Halaris, A;Selemon, LD
背景：双相障碍(BPD)是一种精神疾病，抑郁和躁狂通常交替出现，两个阶段都可以表现出精神病的特征。因此，BPD的症状类似于严重抑郁障碍(MDD)和精神分裂症(SCHZ)，构成了诊断难题。方法：采用三维形态计量学方法对10例抗II级匹配的BPD患者死后大脑背外侧前额叶9区进行分析。结果：BPD 9区的特点是III层神经元密度降低(16%~22%)，III层锥体细胞密度降低(17%~30%)。结论：BPD的形态特征，即与胶质细胞肥大相关的神经元和胶质细胞密度降低，与先前报道的SCHZ的神经元密度升高不同，而与MDD的细胞密度降低相似。因此，BPD和SCHZ之间的神经病理差异表明不同的精神疾病，每种疾病都有特定神经回路的独特形态障碍。(C)2001年生物精神病学学会。
Background: Bipolar disorder (BPD) is a mental illness in which depression and mania typically alternate, and both phases can present with psychotic features. The symptomatology of BPD, therefore, resembles major depressive disorder (MDD) and schizophrenia (SCHZ), posing diagnostic dilemmas. Distinct alterations in cellular architecture of the dorsolateral prefrontal cortex distinguish SCHZ and MDD, whereas the cellular neuropathology of BPD has not been studied.Methods: Dorsolateral prefrontal area 9 was analyzed using a three-dimensional morphometric method in postmortem brains from 10 BPD patients anti II matched nonpsychiatric control subjects.Results: Area 9 in BPD was characterized by, reduced neuronal density in layer III (16%-22%) and reduced pyramidal cell density in layers III and V (17%-30%). A 19% reduction in glial density tt was found in sublayer IIIc coupled with enlargement and changes in shape of glial nuclei spanning multiple layers.Conclusions: The morphologic signature of BPD, i.e,, decreased neuronal and glial density in association with glial hypertrophy, is distinct from previously described elevations in neuronal density in SCHZ, instead resembling the reductions in cell density found in MDD. Thus, the neuropathologic distinctions between BPD and SCHZ al e indicative of separate mental illnesses, each with a unique morphologic disturbance of specific neural circuits. (C) 2001 Society of Biological Psychiatry.