Are flatter diurnal cortisol rhythms associated with major depression and anxiety disorders in late adolescence? The role of life stress and daily negative emotion
Are flatter diurnal cortisol rhythms associated with major depression and anxiety disorders in late adolescence? The role of life stress and daily negative emotion
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DOI：
10.1017/s0954579413000060
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发表时间：
2013-08-01
影响因子：
3.3
通讯作者：
Adam, Emma K.
中科院分区：
文献类型：
--
作者：
Doane, Leah D.;Mineka, Susan;Adam, Emma K.
下丘脑-垂体-肾上腺（HPA）轴功能的改变与重度抑郁症（MDD）和某些焦虑症有关。很少有研究人员测试的可能性，高水平的近期生活压力或负面情绪的升高可能部分解释HPA轴的改变，在这些疾病中观察到。在青年情感项目的300名青少年的样本中，我们研究了抑郁症和焦虑症之间的关联，内化心理学的维度测量，生活压力，皮质醇测试当天的情绪，以及HPA轴功能。与没有内化障碍病史的青少年相比，过去有MDD发作的青少年和最近有MDD发作与焦虑障碍共病的青少年具有更平坦的昼夜皮质醇斜率。更高的报告一般困扰，一个维度的内化心理学，也与平坦的斜坡。消极情绪，特别是悲伤和孤独，与坡度较低有关，并部分解释了共病MDD和焦虑症和皮质醇之间的关联。过去的抑郁症和皮质醇斜率之间的关联并没有被负性情绪，内在化抑郁症的维度变化或生活压力水平所解释，这表明平坦的皮质醇斜率也可能是过去抑郁症经历的“疤痕”标记。
Alterations in hypothalamic-pituitary-adrenal (HPA) axis functioning have been associated with major depression disorder (MDD) and some anxiety disorders. Few researchers have tested the possibility that high levels of recent life stress or elevations in negative emotion may partially account for the HPA axis alterations observed in these disorders. In a sample of 300 adolescents from the Youth Emotion Project, we examined associations between MDD and anxiety disorders, dimensional measures of internalizing symptomatology, life stress, mood on the days of cortisol testing, and HPA axis functioning. Adolescents with a past MDD episode and those with a recent MDD episode comorbid with an anxiety disorder had flatter diurnal cortisol slopes than adolescents without a history of internalizing disorders. Higher reports of general distress, a dimension of internalizing symptomatology, were also associated with flatter slopes. Negative emotion, specifically sadness and loneliness, was associated with flatter slopes and partially accounted for the associations between comorbid MDD and anxiety disorders and cortisol. The associations between past MDD and cortisol slopes were not accounted for by negative emotion, dimensional variation in internalizing symptomatology, or levels of life stress, indicating that flatter cortisol slopes may also be a "scar" marker of past experiences of MDD.