Pursuing Human-Relevant Gut Microbiota-Immune Interactions.
Pursuing Human-Relevant Gut Microbiota-Immune Interactions.
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DOI：
10.1016/j.immuni.2019.08.002
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发表时间：
2019-08
期刊：
影响因子：
32.4
通讯作者：
S. Spencer;G. Fragiadakis;J. Sonnenburg
中科院分区：
文献类型：
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作者：
S. Spencer;G. Fragiadakis;J. Sonnenburg
肠道微生物群是一个复杂的和可塑性的网络，与人类生理学错综复杂地联系在一起。微生物群和免疫系统分析方法的最新进展现在使人们能够更深入地探索免疫-微生物群的联系。下一步的重要工作是阐明与人类相关的微生物免疫连接“地图”，同时专注于动物研究，以探索相互作用的优先子集。在这里，我们提供了一个概述这一领域的现状，并讨论了两种方法来建立详细调查的优先事项：（1）纵向干预研究在人类探测微生物群和免疫系统的动态和（2）传统人群的研究，以评估人类微生物身份的缺失可能会导致免疫疾病的上升失去的功能。这些以人为本的方法为理解微生物群对免疫发育和功能的影响提供了一条明智的途径。
The gut microbiota is a complex and plastic network of diverse organisms intricately connected with human physiology. Recent advances in profiling approaches of both the microbiota and the immune system now enable a deeper exploration of immunity-microbiota connections. An important next step is to elucidate a human-relevant "map" of microbial-immune wiring while focusing on animal studies to probe a prioritized subset of interactions. Here, we provide an overview of this field's current status and discuss two approaches for establishing priorities for detailed investigation: (1) longitudinal intervention studies in humans probing the dynamics of both the microbiota and the immune system and (2) the study of traditional populations to assess lost features of human microbial identity whose absence may be contributing to the rise of immunological disorders. These human-centered approaches offer a judicious path forward to understand the impact of the microbiota in immune development and function.