Anaerobic Dehalogenation of Hydroxylated Polychlorinated Biphenyls by Desulfitobacterium dehalogenans
Anaerobic Dehalogenation of Hydroxylated Polychlorinated Biphenyls by Desulfitobacterium dehalogenans
复制标题
脱卤脱硫杆菌对羟基多氯联苯的厌氧脱卤
DOI：
10.1128/aem.65.5.2217-2221.1999
复制
发表时间：
1999
影响因子：
4.4
通讯作者：
Qingzhong Wu
中科院分区：
文献类型：
--
作者：
J. Wiegel;Xiaoming Zhang;Qingzhong Wu
摘要10年前，多氯联苯（PCBs）在沉积物中存在厌氧脱卤现象，而对羟基化PCBs（HO-PCBs）是PCBs在哺乳动物体内的主要代谢产物，在人体内具有雌激素和抗雌激素活性。厌氧细菌Desulfitobacterium dehalogenans可将3，3 ′，5，5 ′-四氯-4，4 ′-二羟基联苯等同系物中的所有邻位氯（对羟基邻位氯）完全脱卤。
ABSTRACT Ten years after reports on the existence of anaerobic dehalogenation of polychlorinated biphenyls (PCBs) in sediment slurries, we report here on the rapid reductive dehalogenation ofpara-hydroxylated PCBs (HO-PCBs), the excreted main metabolites of PCB in mammals, which can exhibit estrogenic and antiestrogenic activities in humans. The anaerobic bacteriumDesulfitobacterium dehalogenans completely dehalogenates all flanking chlorines (chlorines in ortho position to thepara-hydroxyl group) from congeners such as 3,3′,5,5′-tetrachloro-4,4′-dihydroxybiphenyl.