Hypoxic hepatopathy: Pathophysiology and prognosis
Hypoxic hepatopathy: Pathophysiology and prognosis
复制标题
DOI：
10.2169/internalmedicine.46.0059
复制
发表时间：
2007-01-01
影响因子：
1.2
通讯作者：
Takara, Tsuyoshi
中科院分区：
文献类型：
--
作者：
Birrer, Richard;Takuda, Yasuharu;Takara, Tsuyoshi
背景在低灌注状态下，某些患者的血清肝酶浓度会出现短暂的急剧升高。由于发病机制被认为是局部缺血，这种疾病被称为“休克性肝”或“缺血性肝炎”。然而，低血压或休克并不总是present.Methods我们分析了293例（322集）谁有一个缺氧状态，并承认在两个综合性hospital.Results重症监护病房的医疗记录约1%的患者在重症监护入院。除低血压外，肝损伤的原因还包括继发于充血性心力衰竭的低血流状态和败血症或呼吸衰竭引起的缺氧以及各种病因引起的低氧血症。这些值大多是正常的几天内，当缺氧病因得到纠正，严重的共病状态没有interview.Conclusion肝酶显着升高，不仅可以确定在低血压患者，但也在正常血压的患者在缺氧状态。因此，这种情况被适当地称为缺氧性肝病。
Background Dramatic transient elevation in serum concentrations of hepatic enzymes occurs in some patients following a hypo-perfusion state. This entity is variously termed "shock liver" or "ischemic hepatitis", since the pathogenesis is considered to be ischemia. However, hypotension or shock is not always present.Methods We analyzed the medical records of 293 patients (322 episodes) who had a hypoxic state and were admitted to the critical care units of two general hospitals over a 13-year period.Results Hepatic injury was identified in about 1% of patients in critical care admissions. In addition to hypotension, the causes for hepatic injury were a low flow state secondary to congestive heart failure and hypoxia from sepsis or respiratory failure and hypoxemia from a variety of etiologies. These values were mostly normalized within several days when the hypoxic etiology was corrected and a serious co-morbid state did not intervene.Conclusion Marked elevation of hepatic enzymes can be identified not only in patients with hypotension, but also in normotensive patients in hypoxic state. Thus, the condition is appropriately termed hypoxic hepatopathy.