In vitro cardiac tissue models: Current status and future prospects.
In vitro cardiac tissue models: Current status and future prospects.
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DOI：
10.1016/j.addr.2015.09.011
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发表时间：
2016-01-15
影响因子：
16.1
通讯作者：
Healy KE
中科院分区：
文献类型：
--
作者：
Mathur A;Ma Z;Loskill P;Jeeawoody S;Healy KE
心血管疾病是世界范围内导致死亡的主要原因。实现下一阶段的潜在治疗策略和更好的预后工具将需要跨学科领域的共同努力。基于生物材料的心脏组织模型正在彻底改变临床前研究和转化应用领域。体外心脏组织建模的目标是建立人体心肌的生理功能模型，由于人类心脏的复杂结构和功能，这是一项艰巨的任务。本文综述了利用生物材料和生物启发平台在体外心脏模型领域取得的进展。该领域在过去十年中取得了广泛的进展，我们设想它在药物筛选，疾病建模和精准医学领域的应用。
Cardiovascular disease is the leading cause of death worldwide. Achieving the next phase of potential treatment strategies and better prognostic tools will require a concerted effort from interdisciplinary fields. Biomaterials-based cardiac tissue models are revolutionizing the area of preclinical research and translational applications. The goal of in vitro cardiac tissue modeling is to create physiological functional models of the human myocardium, which is a difficult task due to the complex structure and function of the human heart. This review describes the advances made in area of in vitro cardiac models using biomaterials and bioinspired platforms. The field has progressed extensively in the past decade, and we envision its applications in the areas of drug screening, disease modeling, and precision medicine.