Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies
Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies
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DOI：
10.3945/jn.112.172049
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发表时间：
2013-03-01
影响因子：
4.2
通讯作者：
Nettleton, Jennifer A.
中科院分区：
文献类型：
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作者：
Hruby, Adela;Ngwa, Julius S.;Nettleton, Jennifer A.
在观察性和临床研究中观察到镁摄入量与血糖性状（如空腹血糖和胰岛素）之间的有利关联，但遗传变异是否会影响这些关联在很大程度上是未知的。我们假设与血糖性状或镁代谢相关的单核苷酸多态性（SNP）影响镁摄入量与空腹血糖和胰岛素之间的关联。来自CHARGE（基因组流行病学心脏和衰老研究队列）联盟的15项研究提供了多达52，684名欧洲血统参与者的数据，这些参与者没有已知的糖尿病。在固定效应荟萃分析中，我们量化了1）膳食镁摄入量与空腹血糖（mmol/L）和胰岛素（In-pmol/L）的横截面相关性，以及2）镁摄入量与空腹血糖（16个SNP）、胰岛素（2个SNP）或镁（8个SNP）对空腹血糖和胰岛素相关SNP之间的相互作用。在调整了年龄、性别、能量摄入、BMI和行为风险因素后，（每50 mg/d增量）与空腹血糖呈负相关[β = -0.009 mmol/L（95% CI：-0.013，-0.005），P< 0.0001]和胰岛素（-0.020 In-pmo/L（95% CI：-0.024，-0.017），P< 0.0001]。在多次测试校正后，没有镁相关的SNP或任何SNP与镁之间的相互作用达到显著性。然而，编码镁转运蛋白的TRPM 6中的rs 2274924显示与葡萄糖的标称关联（未校正的P= 0.03），SLC 30 A8中的rs 11558471和CNNM 2附近的rs3740393显示与镁对葡萄糖的标称相互作用（未校正的，均P = 0.02）。与其他研究一致，较高的镁摄入量与较低的空腹血糖和胰岛素相关。TRPM 6的影响和镁与选择位点的相互作用的名义证据表明，需要进一步的调查。J.营养143：345-353，2013.
Favorable associations between magnesium intake and glycemic traits, such as fasting glucose and insulin, are observed in observational and clinical studies, but whether genetic variation affects these associations is largely unknown. We hypothesized that single nucleotide polymorphisms (SNPs) associated with either glycemic traits or magnesium metabolism affect the association between magnesium intake and fasting glucose and insulin. Fifteen studies from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium provided data from up to 52,684 participants of European descent without known diabetes. In fixed-effects meta-analyses, we quantified 1) cross-sectional associations of dietary magnesium intake with fasting glucose (mmol/L) and insulin (In-pmol/L) and 2) interactions between magnesium intake and SNPs related to fasting glucose (16 SNPs), insulin (2 SNPs), or magnesium (8 SNPs) on fasting glucose and insulin. After adjustment for age, sex, energy intake, BMI, and behavioral risk factors, magnesium (per 50-mg/d increment) was inversely associated with fasting glucose [beta = -0.009 mmol/L (95% CI: -0.013, -0.005), P< 0.0001] and insulin (-0.020 In-pmo/L (95% CI: -0.024, -0.017), P< 0.0001]. No magnesium-related SNP or interaction between any SNP and magnesium reached significance after correction for multiple testing. However, rs2274924 in magnesium transporter-encoding TRPM6 showed a nominal association (uncorrected P= 0.03) with glucose, and rs11558471 in SLC30A8and rs3740393 near CNNM2showed a nominal interaction (uncorrected, both P = 0.02) with magnesium on glucose. Consistent with other studies, a higher magnesium intake was associated with lower fasting glucose and insulin. Nominal evidence of TRPM6 influence and magnesium interaction with select loci suggests that further investigation is warranted. J. Nutr. 143: 345-353, 2013.