Metabolic reprogramming in renal cancer: Events of a metabolic disease.
Metabolic reprogramming in renal cancer: Events of a metabolic disease.
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DOI：
10.1016/j.bbcan.2021.188559
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Pal S
中科院分区：
文献类型：
--
作者：
Chakraborty S;Balan M;Sabarwal A;Choueiri TK;Pal S
最近的研究表明，肿瘤可以重新编程参与营养摄取和代谢的途径，以承受癌细胞改变的生物合成、生物能量学和氧化还原需求。这种现象被称为代谢重编程，它是由肿瘤抑制基因的缺失和癌基因的激活所促进的。由于多种代谢途径的改变和扰动，肾细胞癌（RCC）有时被称为“代谢性疾病”。肾癌中大部分代谢重编程是由von Hippel-Lindau （VHL）基因失活和Ras-PI3K-AKT-mTOR通路激活引起的。缺氧诱导因子（HIF）和Myc是RCC代谢重编程的其他重要参与者。所有类型的rcc都与葡萄糖、脂肪酸代谢和三羧酸（TCA）循环的重编程有关。谷氨酰胺、色氨酸和精氨酸的代谢也在肾癌中被重新编程，以促进肿瘤的生长和肿瘤的发生。总之，详细了解这些代谢途径的修饰或重编程为开发新的治疗靶点和策略、发现生物标志物和确定有效的肿瘤检测方法提供了充分的机会。
Recent studies have established that tumors can reprogram the pathways involved in nutrient uptake and metabolism to withstand the altered biosynthetic, bioenergetics and redox requirements of cancer cells. This phenomenon is called metabolic reprogramming, which is promoted by the loss of tumor suppressor genes and activation of oncogenes. Because of alterations and perturbations in multiple metabolic pathways, renal cell carcinoma (RCC) is sometimes termed as a “metabolic disease”. The majority of metabolic reprogramming in renal cancer is caused by the inactivation of von Hippel-Lindau (VHL) gene and activation of the Ras-PI3K-AKT-mTOR pathway. Hypoxia-inducible factor (HIF) and Myc are other important players in the metabolic reprogramming of RCC. All types of RCCs are associated with reprogramming of glucose and fatty acid metabolism and the tricarboxylic acid (TCA) cycle. Metabolism of glutamine, tryptophan and arginine is also reprogrammed in renal cancer to favor tumor growth and oncogenesis. Together, understanding these modifications or reprogramming of the metabolic pathways in detail offer ample opportunities for the development of new therapeutic targets and strategies, discovery of biomarkers and identification of effective tumor detection methods.
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影响因子：
4.6
作者：
Balan M;Chakraborty S;Flynn E;Zurakowski D;Pal S
通讯作者：
Pal S
影响因子：
11.2
作者：
Abu Aboud O;Habib SL;Trott J;Stewart B;Liang S;Chaudhari AJ;Sutcliffe J;Weiss RH
通讯作者：
Weiss RH
影响因子：
3.7
作者：
Chowdhury B;Porter EG;Stewart JC;Ferreira CR;Schipma MJ;Dykhuizen EC
通讯作者：
Dykhuizen EC
影响因子：
--
作者：
Bianchi C;Meregalli C;Bombelli S;Di Stefano V;Salerno F;Torsello B;De Marco S;Bovo G;Cifola I;Mangano E;Battaglia C;Strada G;Lucarelli G;Weiss RH;Perego RA
通讯作者：
Perego RA
影响因子：
--
作者：
De Luca A;Fiorillo M;Peiris-Pagès M;Ozsvari B;Smith DL;Sanchez-Alvarez R;Martinez-Outschoorn UE;Cappello AR;Pezzi V;Lisanti MP;Sotgia F
通讯作者：
Sotgia F