Relaxin stimulates collagenase and plasminogen activator secretion by dispersed human amnion and chorion cells in vitro.
Relaxin stimulates collagenase and plasminogen activator secretion by dispersed human amnion and chorion cells in vitro.
复制标题
松弛素在体外刺激分散的人羊膜和绒毛膜细胞分泌胶原酶和纤溶酶原激活剂。
DOI：
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发表时间：
1983
影响因子：
5.8
通讯作者：
G. Bryant
中科院分区：
文献类型：
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作者：
E. Koay;C. K. Too;F. Greenwood;G. Bryant
分别用松弛素和无松弛素培养人羊膜和绒毛膜分散细胞。在培养液中加入这种激素可使胶原酶和纤溶酶原激活剂在32小时内的分泌量增加，但对蛋白聚糖酶和β -葡萄糖醛酸酶的分泌没有影响。纤溶酶原激活物的增加与体外松弛素添加量呈剂量相关。结果表明，胎儿膜是松弛素在人体中的新靶组织，体内松弛素可能引起类似的胶原溶解酶的释放，导致胎膜变弱并最终破裂。
Dispersed cells from human amnion and chorion were cultured with and without relaxin. The addition of this hormone caused an increased secretion of both collagenase and plasminogen activator into the culture medium over a 32 h period, but had no effect on proteoglycanase or beta-glucuronidase secretion. The increase in plasminogen activator was dose-related to the amount of relaxin added in vitro. The results show that the fetal membranes are a novel target tissue for relaxin in the human, and suggest that relaxin in vivo may cause a similar release of collagenolytic enzymes, leading to the weakening and eventual rupture of the fetal membranes.