Correlations between C-reactive protein, interleukin-6, tumor necrosis factor-α and body mass index during senile osteoporosis
Correlations between C-reactive protein, interleukin-6, tumor necrosis factor-α and body mass index during senile osteoporosis
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DOI：
10.1016/s0167-4943(98)00110-1
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发表时间：
1998-09-01
影响因子：
4
通讯作者：
Malaguarnera, M
中科院分区：
文献类型：
--
作者：
Maugeri, D;Russo, MS;Malaguarnera, M
对36名平均年龄为76.8 ± 4.5岁的老年受试者（18名男性，18名女性）进行了C-反应蛋白（CRP）、白细胞介素-6（I1-6）和肿瘤坏死因子-α（TNF-α）的血清浓度以及体重指数（BMI）的测定，以评估这些参数是否与老年性骨质疏松症（SOP）有关。通过双发射X射线吸收测定法（dexa）对非优势半径测定骨矿物质密度，作为SOP的测量值。这些研究揭示了以下主要结果：（i）在该年龄段SOP的女性/男性比例为4：1;（ii）超重对女性的SOP具有某种保护作用;（iii）在任何性别中观察到的血清I 1 -6和TNF-α水平升高均伴有SOP，表明这些参数可能参与SOP的激发和维持;（iv）血清CRP水平升高表明，在大多数老年受试者中，SOP中存在炎症，这在以前被认为仅仅是“磨损"引起的疾病。(C)1998爱思唯尔科学爱尔兰有限公司。保留所有灯光。
Serum concentrations of C-reactive protein (CRP), interleukin-6 (I1-6) and tumor necrosis factor-alpha (TNF-alpha), as well as body mass index (BMI) were measured in a series of 36 elderly subjects (18 males, 18 females) of mean age 76.8 +/- 4.5 years, in order to assess whether these parameters are involved in senile osteoporosis (SOP). Bone mineral density was determined, by a dual-emission X-ray absorbimetry (dexa) method on the nondominant radius, as a measure of SOP. These studies revealed the following main results: (i) the female/male ratio of SOP at this age is 4:1; (ii) overweight has a sort of protection against SOP in females; (iii) increased I1-6 and TNF-alpha serum levels when observed in either of the sexes were accompanied by SOP, indicating that these parameters may be involved in provoking and maintaining SOP; (iv) elevated serum CRP levels indicate, in most elderly subjects, the presence of inflammation in SOP which has been considered previously as a merely 'wear and tear'-induced disease. (C) 1998 Elsevier Science Ireland Ltd. All lights reserved.