Nanoscale molecular cavities for stabilization of highly reactive species
Nanoscale molecular cavities for stabilization of highly reactive species
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DOI：
10.5059/yukigoseikyokaishi.63.1157
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发表时间：
2005-11-01
影响因子：
0.2
通讯作者：
Kawashima, T
中科院分区：
文献类型：
--
作者：
Goto, K;Kawashima, T
设计了几种碗型分子，用于调节其空腔中官能团的反应性，特别是用于常规方法难以获得的高活性物种的动力学稳定。这些分子空腔的“外围空间保护”有效地防止了反应性物种的双分子分解，例如二聚或自缩合，并且能够分离各种物种，包括次磺酸、硒酸、S-亚硝基硫醇。和Se-亚硝基硒醇，它们已知是生物反应中重要但难以实现的中间体。利用分子碗作为过渡金属配合物的配体也被描述。
Several kinds of bowl-type molecules were designed for regulation of the reactivities of the functional groups in their cavities, especially for kinetic stabilization of highly reactive species which have been difficult of access by conventional methods. The "peripheral steric protection" by these molecular cavities effectively prevents the bimolecular decomposition of the reactive species such as dimerization or self-condensation, and enabled the isolation of various species including a sulfenic acid, a selenenic acid, an S-nitrosothiol. and a Se-nitrososelenol, which have been known as important but elusive intermediates in biological reactions. Utilization of the molecular bowls as the ligands for transition metal complexes is also described.