Desperately seeking subunits:: are native 5-HT3 receptors really homomeric complexes?
Desperately seeking subunits:: are native 5-HT3 receptors really homomeric complexes?
复制标题
DOI：
10.1016/s0165-6147(98)01210-3
复制
发表时间：
1998-06-01
影响因子：
13.8
通讯作者：
Barnes, NM
中科院分区：
文献类型：
--
作者：
Fletcher, S;Barnes, NM
5-HT3 受体复合物是配体门控离子通道，因此可能包含与该超家族其他成员相同的多个亚基。然而，迄今为止，仅鉴定出一种 5-MT3 受体亚基以及一种选择性剪接变体。在本文中，Stephanie Fletcher 和 Nicholas Barnes 回顾了文献中的一些大量数据，这些数据表明存在其他 5-HT3 受体亚基。鉴于最近证明从猪脑中纯化的 5-HT3 受体含有非 5-HT3A 样蛋白，这一点尤其重要。
The 5-HT3 receptor complex is a ligand-gated ion channel, and is therefore likely to comprise multiple subunits in common with other members of this superfamily. To date, however, only one 5-MT3 receptor subunit, plus an alternatively spliced variant, have been identified. In this article, Stephanie Fletcher and Nicholas Barnes review some of the extensive data in the literature that suggest the presence of other 5-HT3 receptor subunits, This is particularly relevant given the recent demonstration that the 5-HT3 receptor purified from pig brain contains a non-5-HT3A-like protein(s).