Embryonic reversions and lineage infidelities in tumour cells: genome‐based models and role of genetic instability
Embryonic reversions and lineage infidelities in tumour cells: genome‐based models and role of genetic instability
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肿瘤细胞中的胚胎逆转和谱系不忠：基于基因组的模型和遗传不稳定性的作用
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
L. Bignold
中科院分区：
文献类型：
--
作者：
L. Bignold
自19世纪以来，“胚胎干细胞”型细胞的逆转和肿瘤细胞谱系的不完整性（包括化生）已被认为是各种肿瘤类型的一个方面。从那时起，这些现象的证据已经从许多临床，生物化学，免疫学和分子生物学研究中获得。特别是，微阵列研究表明，相关基因的“异常”表达是常见的。这些研究结果的一个无法解释的方面是，在许多肿瘤类型中，胚胎逆转或谱系不忠只发生在一部分病例中。在过去几十年中，作为肿瘤分子生物学研究的一个平行发展，至少在某些肿瘤细胞制剂中，遗传不稳定性被发现比以前通过肿瘤核型研究所确定的要明显得多。这项研究回顾了胚胎逆转和谱系不忠现象的例子，这些现象来自过去150年左右对癌症的各种研究。已经确定了四类发生胚胎逆转或谱系不完整的情况-（i）作为肿瘤的定义表型的一部分，因此可能是肿瘤类型的组成部分，（ii）仅在某些肿瘤类型的病例中从头开始存在，并且可能与肿瘤类型的基本特征定期相关，但偶然发生，（iii）在疾病过程的后期发生，因此可能是体内遗传不稳定性和“肿瘤进展”的表现，以及（iv）在与离体研究相关的过程中，特别是细胞培养过程中，可能由遗传不稳定性引起。基因组模型的描述可能占这些现象的起源，在每一个这些情况下。
Reversions to ‘embryonic precursor’‐type cells and infidelities of tumour cell lineage (including metaplasias) have been recognized as aspects of various tumour types since the 19th century. Since then, evidence of these phenomena has been obtained from numerous clinical, biochemical, immunological and molecular biological studies. In particular, microarray studies have suggested that ‘aberrant’ expressions of relevant genes are common. An unexplained aspect of the results of these studies is that, in many tumour types, the embryonic reversion or lineage infidelity only occurs in a proportion of cases. As a parallel development during the molecular biological investigation of tumours over the last several decades, genetic instability has been found much more marked, at least in some preparations of tumour cells, than that identified by means of previous karyotypic investigations of tumours. This study reviews examples of embryonic reversion and lineage infidelity phenomena, which have derived from the various lines of investigation of cancer over the last 150 or so years. Four categories of circumstances of the occurrence of embryonic reversions or lineage infidelities have been identified – (i) as part of the defining phenotype of the tumour, and hence being presumably integral to the tumour type, (ii) present ab initio in only some cases of the tumour type, and presumably being regularly associated with, but incidental to, the essential features of the tumour type, (iii) occurring later in the course of the disease and thus being possibly a manifestation of in vivo genetic instability and ‘tumour progression’ and (iv) arising probably by genetic instability, during the processes, especially cell culture, associated with ex vivo investigations. Genomic models are described which might account for the origin of these phenomena in each of these circumstances.
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DOI：
10.1159/000147748
发表时间：
1995
期刊：
Acta anatomica
影响因子：
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作者：
E. Hay
通讯作者：
E. Hay
驱动果蝇入侵和迁移的基因。
影响因子：
4
作者：
Starz-Gaiano,Michelle;Montell,DeniseJ
通讯作者：
Montell,DeniseJ
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影响因子：
0.4
作者：
Fu, J. J.;Khan, M. A.;Cheng, J. L.
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Cheng, J. L.
影响因子：
11.2
作者：
L. Loeb
通讯作者：
L. Loeb
“主”转录因子在人类白血病和肉瘤中的致癌作用：发育模型。
影响因子：
--
作者：
Look,AT
通讯作者：
Look,AT