Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro
Transient exposure to PTHrP (107-139) exerts anabolic effects through vascular endothelial growth factor receptor 2 in human osteoblastic cells in vitro
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DOI：
10.1007/s00223-006-0099-y
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发表时间：
2006-11-01
影响因子：
4.2
通讯作者：
Esbrit, P.
中科院分区：
文献类型：
--
作者：
de Gortazar, A. R.;Alonso, V.;Esbrit, P.
间歇性施用甲状旁腺激素 (PTH) 的 N 末端片段和 PTH 相关蛋白 (PTHrP) 会诱导骨合成代谢作用。然而，PTHrP C 端结构域对骨转换的影响仍存在争议。我们使用人骨肉瘤 MG-63 细胞和来自人骨小梁的成骨细胞检查了 PTHrP 结构域影响成骨细胞分化的推定机制。间歇性暴露于 PTHrP (107-139)，在 10-100 nM 范围内，仅用于
Intermittent administration of the N-terminal fragment of parathyroid hormone (PTH) and PTH-related protein (PTHrP) induces bone anabolic effects. However, the effects of the C-terminal domain of PTHrP on bone turnover remain controversial. We examined the putative mechanisms whereby this PTHrP domain can affect osteoblastic differentiation, using human osteosarcoma MG-63 cells and osteoblastic cells from human trabecular bone. Intermittent exposure to PTHrP (107-139), within 10-100 nM, for only